舌下含服粉尘螨滴剂联合鼻用激素治疗变应性鼻炎疗效观察

目的 评估舌下特异性免疫治疗联合鼻用激素治疗变应性鼻炎的疗效。方法 将能坚持治疗并定期随访的90例对粉尘螨过敏的变应性鼻炎患者资料纳入研究，随机分为两组，其中60例接受舌下免疫治疗(SLIT)联合鼻用激素治疗，另30例只用鼻用激素治疗，分别记录两组患者治疗前及治疗后6、12个月的症状评分(鼻痒、喷嚏、流涕、鼻塞症状评分)和症状总评分。结果 两组治疗后鼻炎症状均有显著改善，差异有统计学意义(P<0.05)；联合治疗组12个月后较治疗6个月后鼻炎症状改善更显著(P<0.05)，而单用激素组未再有明显改善(P>0.05)；联合治疗组较单用激素组无论6个月后还是12个月后症状改善均更为显著(P<0.05)。结论 舌下特异性免疫治疗联合鼻用激素治疗变应性鼻炎较单用激素更为有效。

Clinical efficacy of sublingual dermatophagoides farinae drops in combination with intranasal steroids in treat-ment of allergic rhinitis

Objective To evaluate the clinical efficacy of sublingual immunotherapy(SLIT) in the treatment of allergic rhinitis in combination with intranasal steroids. Methods Ninety AR patients were randomly divided into two groups: 60 patients treated by SCIT+steroids and the other 30 patients only treated with intranasal steroids. The nasal symptom scores of pruritus, sneezing, rhinorrhea and nasal obstruction were evaluated using a four-point raiting scale (from 0=absent to 3=severe) before the treatment and six months and a year after the treatment. Then the scores were compared. Results The nasal symptom scores of all patients were significantly decreased after treatment(P<0.05), and the symptoms after treatment were alleviated more significantly after one year than after 6 months in the combination group(P<0.05). However, there were no significant difference between the two periods in the single nasal spray group (P>0.05). The scores of nasal symptom in the combination group were significant lower than the single nasal spray group whether after 6 months or after 12 months. Conclusion Combination therapy of SLIT and intranasal steroids is more effective for allergic rhinitis than intranasal steroids alone.