甘草锌颗粒联合硼酸溶液局部外涂治疗轻中度寻常性痤疮疗效观察

目的:观察甘草锌颗粒口服联合硼酸溶液局部外涂治疗轻中度寻常性痤疮的疗效。方法:将109例轻中度(I~Ⅲ级)寻常性痤疮患者随机分为三组:A组(治疗组):给予甘草锌颗粒口服联合3%硼酸溶液外涂;B组(B对照组):给予甘草锌颗粒口服;C组(C对照组):给予3%硼酸溶液外涂。三组疗程均为6周,疗程结束后根据皮损数目减少及患者症状的改善情况进行疗效评估。结果:A、B、C三组痊愈分别为12例(32.4%)、3例(13.9%)、4例(12.5%),三组总有效率分别为81.1%、38.9%、40.7%,三组总有效率比较差别具有统计学意义(P0.01),A、B两组和A、C两组分别比较差别均具有统计学意义(P0.01);但B、C两组比较差别无统计学意义(P0.05)。结论:甘草锌颗粒口服联合硼酸溶液局部外涂治疗轻中度寻常性痤疮疗效满意,不良反应少,方法简便,值得推广。

Observation on clinical effects of combination therapy of Licorzinc granules and boric acid solution in the treatment of acne vulgaris

Objective To explore the clinical efficacy and safety of combination therapy of Licorzinc granules and boric acid solution in the treatment of acne vulgaris.Methods 109 cases with acne vulgaris （Ⅰ～ Ⅲ grade） were randomly selected and divided into three groups：combination group（A group）,control B group and control C group.A group were treated with combined licorzinc granules with 3％ boric acid solution,while B group received treatment of only oral licorzinc granules and C group received treatment of only 3％ boric acid solution.Each groups were 6 weeks of treatment externally.skin changes in lesions were recorded and adverse reactions were observed,the efficacy was assessmented based on reducing the number of skin lesions and the patient＇s symptoms score to improve after the end of treatment.Results A、B、C three groups were cured 12 cases （32.4％）,3cases（13.9％）,4 cases（12.5％）,and the total response rates of the three groups were 81.1％（30 cases）,38.9％ （14 cases）,40.7％ （13 cases）respectively,there were significant difference between the three groups （P ＜0.01）.compared with control B and C group,response rate of combination A group increased significantly （P＜0.01）,more significantly in combination A group （P＜0.01）.But there were no significant difference between B group and C group （P＞0.05）.Side effects were observed in control group and combination group,minor side effects disappeared in three groups after treatments were over.Conclusion Combination therapy of licorzinc granules and boric acid solution shows positive effect in the treatment of acne vulgaris,high cure rate,minor side effects and method is simple and worth promoting.