中枢白细胞介素-1β介导束缚应激性升压反应的中枢机制

目的:研究中枢白细胞介素-1β(IL-1β)在束缚应激诱发的升压反应的中枢机制。方法:利用清醒大鼠心血管遥感监测系统、脑立体定位微量注射系统、神经电生理记录系统来观察中枢IL-1β在束缚应激诱发的升压反应机制中的作用;以及与延髓头端腹外侧区神经元放电变化之间的关系。结果:束缚应激可诱导升压反应,侧脑室注射IL-1ra可衰减束缚应激诱导的升压反应;直接将IL-1β注入侧脑室亦可诱导大鼠血压升高,同时伴有延髓头端腹外侧区神经元细胞外放电频率增加,二者呈明显的相关关系(r=0.98,P<0.05)。结论:中枢IL-1β介导束缚应激诱发的升压反应,其作用机制与延髓头端腹外侧区密切相关。

Central mechanism of intracerebral interleukin-1β on pressor response induced by restraint stress

AIM: To study the central mechanism of intracerebral interleukin-1β in restraint stress-induced pressor response in rats. METHODS: Cardiovascular radio-telemetry system, stereotaxic micioinjection system and neuroelecttophysiological methods were used to investigate the role of intracerebral interleukin-1β in pressor re-sponse induced by restraint stress,and the relation with the changes of discharge in the rostral ventrolateral medulla (RVL) neuron.RESULTS: The pressor response was induced by restraint stress and was reduced by intracerebralventricular injection of (icv) IL-1 receptor antagonist (IL-1ra) in conscious rats. The pressor response was directly induced by IL-1(icv), which is related to increase of the extracellular discharge frequency in RVL neurons. CONCLUSION::Intracerebral IL-1β mediates pressor response induced by restraint stress，the mechanism may be closely related to RVL.