| 肺癌恶性胸水中CD4+CD25+Foxp3+调节性T细胞检测及其临床意义 |
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| 引用本文： | 曾刚,李威,孟星君. 肺癌恶性胸水中CD4+CD25+Foxp3+调节性T细胞检测及其临床意义[J]. 湖北民族学院学报(医学版 ), 2011, 28(3): 7-10 |
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| 作者姓名： | 曾刚 李威 孟星君 |
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| 作者单位： | 1. 南京医科大学附属苏州医院呼吸科 江苏苏州215006
2. 苏州市立医院肿瘤诊疗中心肿瘤实验室 江苏苏州215006 |
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| 基金项目： | 南京医科大学科技发展基金项目(09NJMVM141); 苏州市科技应用基础研究项目(SYS201050) |
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| 摘 要： | 目的 检测晚期肺癌患者外周血及恶性胸水中CD4+ CD25+ Foxp3+调节性T细胞(CD4+CD25+ Foxp3 +Treg,Foxp3 +Treg)及相关细胞因子的表达情况并探讨其临床意义.方法 通过密度梯度离心法获得26例晚期肺癌患者外周血、胸水中淋巴细胞及上清和10例健康志愿者(对照组)外周血淋巴细胞及上清...
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| 关 键 词： | 肺癌 恶性胸水 调节性T细胞 白细胞介素-10 |
Detection of CD4~+CD25~+Foxp3~+Regulatory T Cells in Malignant Pleural Effusion of Lung Cancer and Its Clinical Significance |
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| ZENG Gang,LI Wei,MEN Xing-jun. Detection of CD4~+CD25~+Foxp3~+Regulatory T Cells in Malignant Pleural Effusion of Lung Cancer and Its Clinical Significance[J]. Journal of Hubei Institute For Nationalities(Medical Edition), 2011, 28(3): 7-10 |
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| Authors: | ZENG Gang LI Wei MEN Xing-jun |
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| Affiliation: | ZENG Gang1,LI Wei1,MEN Xing-jun2(1.Department of Respiratory Medicine,Affiliated Suzhou Hospital,Suzhou 215006,China,2.Department of Medical Oncology,Suzhou Municipal Hospital,China) |
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| Abstract: | Objective To investigate the expression of CD4+CD25+Foxp3+Treg(Foxp3+Treg) and cytokine levels in serum and malignant pleural effusion(MPE)in patients with advanced lung cancer and its clinical significance.Methods Lympholeukocyte and supernatant in peripheral blood(PB)and pleural effusion(PE)were isolated from 26 patients with advanced lung cancer by density gradient centrifugation.Peripheral blood Lympholeukocyte and serum from 10 healthy subjects(control group) were also prepared.The percentages of Foxp3... |
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| Keywords: | lung cancer malignant pleural effusion CD4 CD25 Foxp3 Treg IL-10 |
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