| 注射用辛芍(冻干粉针)与常用输液配伍稳定性研究 |
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| 引用本文： | 何迅,李勇军,王爱民,刘丽娜,周雯,王永林,兰燕宇. 注射用辛芍(冻干粉针)与常用输液配伍稳定性研究[J]. 中国实验方剂学杂志, 2008, 14(5): 9-11 |
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| 作者姓名： | 何迅 李勇军 王爱民 刘丽娜 周雯 王永林 兰燕宇 |
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| 作者单位： | 贵阳医学院,药学院,贵州,贵阳,550004 |
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| 基金项目： | 贵州省中药现代化科技产业研究开发专项基金项目(黔科合农字[2005]500102、[2006]5003号);贵州省省长基金[2005]296号 |
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| 摘 要： | 目的研究注射用辛芍(冻干粉针)在5%葡萄糖和0.9%氯化钠两种输液中的配伍稳定性.方法采用高效液相色谱法测定芍药苷和野黄芩苷在输液中含量及指纹图谱,同时观察输液的外观性状和pH值.结果注射用辛芍(冻于粉针)与5%葡萄糖注射液和0.9%氯化钠注射液配伍后,在室温10 h内,其色泽、pH值、不溶性微粒、芍药苷和野黄芩苷含量、指纹图谱稳定.结论在室温条件下10 h内,注射用辛芍(冻干粉针)可与上述两种输液配伍使用.
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| 关 键 词： | 注射用辛芍(冻干粉针) 配伍稳定性 高效液相色谱法 指纹图谱 |
| 文章编号： | 1005-9903(2008)05-0009-03 |
| 收稿时间： | 2007-09-03 |
| 修稿时间： | 2007-09-03 |
Stability of Xinshao Freeze-dried Powder for Injection in two Kinds of Infusion |
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| HE Xun,LI Yong-jun,WANG Ai-min,LIU Li-n,ZHOU Wen,WANG Yong-lin,LAN Yan-yu. Stability of Xinshao Freeze-dried Powder for Injection in two Kinds of Infusion[J]. China Journal of Experimental Traditional Medical Formulae, 2008, 14(5): 9-11 |
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| Authors: | HE Xun LI Yong-jun WANG Ai-min LIU Li-n ZHOU Wen WANG Yong-lin LAN Yan-yu |
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| Affiliation: | School of Pharmacy,Guiyang Medical College,Guiyang 550004,China |
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| Abstract: | Objective:To study the stability of Xinshao freeze-dried powder for injection in 5% glucose solution and 0.9% sodium chloride solution.Methods: The stability of Xinshao freeze-dried powder for injection was examined by HPLC determining the contents of paeoniflorin and scutellarin,by observing changes in its appearance,pH value and fingerprint chromatogram in 10 h.Results: No changes in color,pH value,insoluble particles,the contents of paeoniflorin and scutellarin and the fingerprint chromatogram.Conclusion: 5% glucose solution and 0.9% sodium chloride solution are compatible with Xinshao freeze-dried powder for injection. |
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| Keywords: | xinshao freeze-dried powder for injection compatible stability HPLC fingerprint chromatogram |
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