肝硬化上消化道出血和幽门螺杆菌感染的相关性研究

目的研究肝硬化患者幽门螺杆菌感染和上消化道出血之间的关系.方法肝硬化患者160例,内镜检查了解食管静脉曲张和消化性溃疡的发生情况及出血的原因,同时胃粘膜活检作尿素酶试验,检测幽门螺杆菌(Hp).结果Hp阳性组消化性溃疡发生率(64.1%)明显高于阴性组(37.8%,P＜0.01).出血率在Hp阳性组(38.5%)也明显高于阴性组(22%,P＜0.05).结论Hp感染和肝源性溃疡发生有关,Hp感染者的肝源性溃疡发生率增高及胃粘膜活动性炎症可能导致出血率升高,根除Hp有可能降低肝硬化上消化道出血.

The relationship between upper gastrointestinal bleeding and Hp infection in patients with liver cirrhosis

Aim To study the relationship between upper gastrointestinal bleeding and Helicobacter pylori(Hp)infection in patients with liver cirrhosis. Methods One hundred and sixty cases with liver cirrhosis were examined endoscopically to observe the degree of varices and incidence of peptic ulcer.Hp was detected by urease test. Results The rate of peptic ulcer in Hp positive group was significantly higher (64.1%)than that in Hp negative group(37.8%, P <0.01).The rate of upper gastrointestinal bleeding in Hp positive group was signifcantly higher (38.5%)than that in Hp negative groups (22%, P <0.05).Conclusions The increased rate of bleeding in Hp positive group was related with the increased incidence of peptic ulcer and active gastritis.Eradication of Hp infection may play an important role in reducing upper gastrointestinal bleeding in liver cirrhosis.