| 棉酚的遗传学研究——Ⅰ.醋酸棉酚对大鼠雄性生殖细胞的细胞遗传学效应和血液中淋巴细胞微核测定的比较研究 |
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| 引用本文： | 张忠恕,潘咸新,王民明,姚玉龙. 棉酚的遗传学研究——Ⅰ.醋酸棉酚对大鼠雄性生殖细胞的细胞遗传学效应和血液中淋巴细胞微核测定的比较研究[J]. 生殖与避孕, 1981, 0(1) |
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| 作者姓名： | 张忠恕 潘咸新 王民明 姚玉龙 |
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| 作者单位： | 上海计划生育科学研究所(张忠恕)，上海医药工业研究院(潘咸新，王民明)，上海医药工业研究院(姚玉龙) |
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| 摘 要： | 本实验观察用醋酸棉酚短期灌服大鼠后雄性生殖细胞的细胞遗传学效应和血液中淋巴细胞微核的染色体损伤效应。给药组的精原细胞和精母细胞所出现的各类染色体畸变平均值虽比对照组高,但两组之间的差异没有统计学意义(P>0.05-0.10)。同样,给药组大鼠血液中淋巴细胞微核出现率也高于对照组,但也无统计学意义(P>0.05)。结果表明,醋酸棉酚对大鼠精原细胞和精母细胞的细胞遗传学效应与血液中淋巴细胞微核的染色体损伤效应的结果是一致的。
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GENETIC STUDIES OF THE GOSSYPOL——Ⅰ.THE COMPARATIVE STUDIES OF CYTOGENETIC EFFECTS OF GOSSYPOL ACETATE ON MALE GERM CELLS AND LYMPHOCYTES IN BLOOD OF THE MICRONUCLEUS TEST IN RATS |
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| Abstract: | This paper presentsd the results of the observations on the cytogenetic effects on male germ cells and blood lymphocytes micronucleus test in rats by short-term after administration of gossypol acetate.The mean frequency of variouschromosomal aberration of the spermatogonia and spermatocytes in gossypol-treated rats,was higher than that of control rats.But the difference was notstatistically significant(p>0.05-0.10).The difference of the mean frequency of micronuclei of the lymphocytesbetween two groups were also not statistically significant(p>0.05).The results showed that the cytogenetic effect of the gossypol acetate on thespermatogonia and spermatocytes was consistent with the effect on chromosomaldamage of micronuclei of lymphocytes in blood. |
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