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| 脑通复方对血管性痴呆大鼠海马尼古丁受体的影响 | |
| 引用本文： | 肖雁,王晓亮,邓婕,闫秀明,黄勇,况时祥,官志忠. 脑通复方对血管性痴呆大鼠海马尼古丁受体的影响[J]. 时珍国医国药, 2010, 21(6) |
| 作者姓名： | 肖雁 王晓亮 邓婕 闫秀明 黄勇 况时祥 官志忠 |
| 作者单位： | 1. 贵阳医学院分子生物学重点实验室,贵州,贵阳,550004 2. 贵阳医学院,贵州,贵阳,550004 3. 贵阳中医学院附属第二医院,贵州,贵阳,550001 |
| 基金项目： | 国家自然科学基金，科技部基金资助项目，贵州省中药现代化专项资助项目 |
| 摘 要： | 目的 观察脑通复方制剂对拟血管性痴呆(VaD)模型大鼠脑组织神经型尼古丁受体(Nicotinic acetylcholine receptors ,nAChR)的影响,分析脑通复方制剂改善血管性痴呆学习记忆能力的作用机制.方法 采用改良Pulsinelli四血管阻断(Pulsinelli's four-vessel occlusion, 4-VO)法复制大鼠血管性痴呆模型,脑通复方制剂治疗后观察学习记忆能力,Western-blot法测定脑组织神经型尼古丁受体蛋白水平.结果 脑通复方制剂可缩短实验大鼠逃避潜伏期,增加跨越平台次数,上调海马组织神经型尼古丁受体的表达.结论 脑通复方制剂可通过上调nAChR表达,从而改善血管性痴呆学习记忆能力. |
| 关 键 词： | 脑通复方制剂 血管性痴呆 学习记忆 神经型尼古丁受体 |
Effect of Nao Tong Compound Recipe on the Expression of Nicotinic Acetylcholine Receptors of Hippocampal in Vascular Dementia Rats |
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| XIAO Yan,WANG Xiao-liang,DENG Jie,YAN Xiu-ming,HUANG Yong,KUANG Shi-xiang,GUAN Zhi-zhong. Effect of Nao Tong Compound Recipe on the Expression of Nicotinic Acetylcholine Receptors of Hippocampal in Vascular Dementia Rats[J]. Lishizhen Medicine and Materia Medica Research, 2010, 21(6) | |
| Authors: | XIAO Yan WANG Xiao-liang DENG Jie YAN Xiu-ming HUANG Yong KUANG Shi-xiang GUAN Zhi-zhong |
| Affiliation: | XIAO Yan1,WANG Xiao-liang1,DENG Jie1,YAN Xiu-ming1,HUANG Yong2,KUANG Shi-xiang3,GUAN Zhi-zhong1(The Key Lab of Medical Molecular Biology,Guiyang Medical College,Guiyang 550004,Guizhou,China) |
| Abstract: | Objective To observe the influnce of Nao Tong Compound Recipe on the nicotinic acetylcholine receptors(nAChR) in rats with vascular dementia(VaD) and to explore the preventive effects of traditional Chinese medicine on spatial learning and memory deficits in rats with VaD.Methods VaD model was created with the reformed Pulsinelli 4-VO method.After establishing the model,the rats were treated with Nao Tong compound recipe.The ability of learning and memory of VaD rats were assessed by Morris Water Maze Test.... |
| Keywords: | Nao Tong Compound Recipe Vascular Dementia Learning and memory Nicotinic acetylcholine receptors |
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