慢性阻塞性肺部疾病的家族聚集性分析

为了判断慢性阻塞性肺部疾病（ＣＯＰＤ）的家族聚集性，探讨遗传因素对ＣＯＰＤ发病的影响，分析了２０６对核心家系的资料。结果表明：ＣＯＰＤ的发病具有家族聚集性。ＣＯＰＤ先证者的亲属（父母、兄弟姐妹）患ＣＯＰＤ的危险性增加，是对照家系亲属（父母、兄弟姐妹）的２．０７倍。除母亲之外，两家系父亲间，兄弟间及姐妹间患ＣＯＰＤ危险性的差异均具有显著性。故ＣＯＰＤ先证者的亲属对ＣＯＰＤ的易感性比对照的亲属高，说明遗传因素是ＣＯＰＤ的危险因素之一。

Analysis of Familial Aggregation of Chronic Obstructive Pulmonary Diseases

Data from 206 pairs of nuclear family members were analyzed to study the influence of genetic factors on the occurrence of chronic obstructive pulmonary disease (COPD) and its familial aggregation.Results showed that occurrence of COPD appeared in family aggregation.Risk of occurrence of COPD in the relatives (father,mother, brothers and sisters )of the proband with COPD increased by 2 07 times,as compared with relatives of the controls.Significant differences of the risk of COPD in fathers,brothers and sisters between proband and controls were observed,but not in mothers.It suggests relatives of the proband are more susceptible to COPD than those of the controls,and genetic factor may contribute to pathogenesis of COPD.