人类β干扰素对乙脑病毒在人类细胞系上增殖的抑制作用

本文研究了人类β干扰素对乙型脑炎病毒在３株人类细胞株上的增殖的抑制作用（Ｈｅｐ－２，ＦＬ和Ｕ９３７）。人类β干扰素在１０００Ｉμ／ｍｌ时，病变产生在ＲＬ细胞，Ｈｅｐ－２细胞和Ｕ９３７细胞上分别是对照组的０．５％，２．７％，３７．２％。本研究同时比较了人类β干扰素在人类细胞株，猴细胞株和地鼠细胞株上对乙脑病毒的抑制作用（Ｈｅｐ－２，Ｖｅｒｏ，ＢＨＫ２１）其敏感性有明确的差异（许多文献已有报道）。本研

Inhibition of Japanese Encephalitis Virus Growth in Human Cell Lines by Human Interferon-beta

The inhibition of the Japanese encephalitis (JE) virus growth by human interferon (IFN)-beta was studied in three human cell lines,ie,Hep-2,FL and U937 cell lines. The growth of JE virus Nabayama strain was more sensitive to human IFN-beta tn FL and Hep-2 cells than in U937 cell line,at 1,000 IU/ml concentration;the yield of JE virus was reduced to 0. 5% of that in the control in FL,2.7% in Hep-2,and 37. 2% in U937 cell line respectively. The IFN concentration to reduce the virus yield to 50% of the control in Hep-2 cell was about 62 IU/ml for JE virus in contrast to 31 IU/ml for Sindbis virus. The inhibitory effect of INF-beta on the growth of JE virus was mare pronounced in human cell line,Hep-2,than in African green monkey kidney cell line,Vero,while significant sensitivity was not observed in hamster kindney cell line,BHK21.