| 新型左心声学超声造影剂空气白蛋白微球制剂的研制 |
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| 引用本文： | 单友亮,侯连兵,陈志良,刘世霆,刘伊丽.新型左心声学超声造影剂空气白蛋白微球制剂的研制[J].中国药房,2002,13(3):138-140. |
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| 作者姓名： | 单友亮 侯连兵 陈志良 刘世霆 刘伊丽 |
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| 作者单位： | 第一军医大学南方医院药学部,广州市,510515 |
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| 基金项目： | 国家新药研究基金项目 (98-02) |
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| 摘 要： | 目的 :对空气人血白蛋白微球制剂的制备工艺进行研究 ,并初步探讨微球形成机理。方法 :按正交设计筛选最佳制备工艺条件 ;库尔特颗粒分析仪测定最佳制备工艺条件下微球粒径 ;光、电镜考察微球外观形态。结果 :最佳制备工艺 :白蛋白生理盐水溶液浓度为5 % ,声振仪功率为9档 ,声振持续时间为60秒。结论 :通过正交试验设计 ,成功研制出含空气的白蛋白微球 ,并能有效地用于左心靶向超声显影诊断
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| 关 键 词： | 超声造影剂 正交设计 人血白蛋白微球 |
| 文章编号： | 1001-0408(2002)03-0138-03 |
| 修稿时间： | 2001年8月27日 |
Preparation of a Newly－ developed Contrast Medium for Echocardiography： Air－albumin Microsphere |
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| SHAN Youliang,HOU Lianbing,CHEN Zhiliang,LIU Shiting,LIU Yili.Preparation of a Newly－ developed Contrast Medium for Echocardiography： Air－albumin Microsphere[J].China Pharmacy,2002,13(3):138-140. |
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| Authors: | SHAN Youliang HOU Lianbing CHEN Zhiliang LIU Shiting LIU Yili |
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| Abstract: | OBJECTIVE:To study the preparation of 5% albumin microspheres by sonication and the possible mechanism of microsphere forming.METHODS:The preparation technic was optimized with orthogonal design.The microsphere diameter was measured with Coulter multisizer and the outward apperance was observed with light and electronic microscope.RESUL_TS:The optimal preparation technic was as follows:5% albumin in NS,ultrasound power at 9th grade and 60 seconds of sonication.CONCLUSION:The albumin microspheres filled with air can be successfully prepared with orthogonal design and can be effectively used in intravenous myocardial contrast echocardiography. |
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| Keywords: | contrast agent for ultrasonic visualization orthogonal design human albumin microsphere |
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