小儿良恶性实体瘤术后sIL-2R变化规律的对比研究

目的：探讨小儿良、恶性实体瘤可溶性白细胞介素2受体（sIL-2R)的表达差异及术后变化规律。方法：采用ELISA双抗体夹心法，对30例恶性实体瘤，15例良性实体瘤和15例健康儿童进行了sIL-2R术前和术后2，3，7动态监测，结果：血清sIL-2R水平在恶性组（988．37u/ml)显著高于良性组（506．40u/ml)，无论良性还是恶性实体瘤患儿均显著高于对照（342.93u/ml)，术后一周观察显示，恶性组sIL-2R呈上升趋势，而良性组则呈下降之态，结论：实体瘤患儿sIL-2R的定量监测，既有助于观察病情和预后判断，也可作为肿瘤性质判断的依据之一。

COMPARATIVE STUDY ON THE CHANGING REGULATION OF sIL-2R IN CHILDREN WITH BENIGN AND MALIGNANT SOLID TUMOR AFTER OPERATION

Objective:To explore the expressive difference of soluble interleukin 2 receptor(sIL 2R) in children with malignant and benign solid tumors,and the changing pattern after operation.Methods:sIL 2R was meaured by ELISA at 1 day before and 2,3,7 days after operation in children with malignant and benign solid tumor.Results:The level of sIL 2R in malignant tumor(998 37u/ml) was significantly higher than that in benign tumor(506 40u/ml),and the level of sIL 2R in either of the two groups was higher than that in the controls(432 93u/ml).One week after operation,the level of sIL 2R tended to increase in malignant group and decrease in benign one.Conclusion:It is helpful to mearue the level of sIL 2R for mastering disease states and predicting development of solid tumors.Meanwhile,the level of sIL 2R can be used as a mark of differentiating malignant from benign tumor.