ThinPrep液基细胞学在宫颈癌筛查中的临床应用

目的:评价ThinPrep液基细胞学对宫颈癌筛查的临床价值.方法:ThinPrep液基细胞学检测了769例妇科病例,同时做宫颈巴氏涂片检测.细胞学诊断采用TBS分级系统,阳性诊断包括意义不明的非典型鳞状上皮细胞(ASCUS)以上的病变,诊断结果与阴道镜下多点组织活检病理结果相对照.结果:ThinPrep液基细胞学检测的敏感性、准确性分别为87.1%、97.3%,而宫颈巴氏细胞学检测的敏感性、准确性分别为68.1%、93.2%,两种方法比较均有显著性差异(P＜0.01).结论:ThinPrep液基细胞学应用于宫颈癌筛查能明显提高宫颈异常细胞诊断的敏感性及准确性,有利于宫颈癌筛查的早期诊断.

Value of ThinPrep liquid - based cytology for the diagnosis of cervical cancer screening

Objective:To evaluate the value of ThinPrep liquid-based cytology for diagnosis of cervical cancer screening.Methods:769 cases were detected by ThinPrep liquid-based cytology and tranditional microscopy respective.the diagnosis criteria were based on The Bethesda System(TBS).The positive results were taken cervical biopsy under guidance of colposcopic for pathological examination.Result:The sensitivity and accuracy of ThinPrep liquid-based cytology detection were 87.1% and 97.3% respectively.The sensitivity and accuracy of tranditional microscopy were 68.1% and 93.2% respectively.The difference was effectively sinficant in the analgesiaefficacy(P<0.01).Conclusion: ThinPrep liquid-based cytology demonstrates good sensitivity and accuracy for the detection of abnormal squamous intraepithelial lesions and squamous cell carcinoma.