泮托拉唑治疗反流性食管炎的疗效

目的：观察国产泮托拉唑和进口奥美拉唑治疗反流性食管炎的疗效和安全性。方法：反流性食管炎患者共60例，随机分为2组，分别口服国产泮托拉唑胶囊40mg和进口奥美拉唑胶囊20mg，早晚各1次，疗程8周，疗程结束后内镜复查。并详细记录不良反应。结果：泮托拉唑组和奥美拉唑组疗效分别为：治愈93．4％和83．3％．有效3．3％和6．7％，显效3．3%和10％(P＞0．05)。2组患者的烧心、反酸、胸骨后灼痛等症状在治疗后的积分值均明显减少(P＜0．01)；胃镜下反流性食管炎(RE)的疗效分别为：无效3．3％和3．3％，有效3．3％和3．3％，显效3．3％和6．7％，治愈90．1％和86．7％(P＞0．05)。2组患者均能良好耐受，末发现严重的不良反应。结论：国产拌托拉唑能明显改善反流性食管炎的临床症状和镜下表现，疗效确切，使用安全。

The efficacy of domestic pantoprazole in treatment of reflux esophagitis

Objective:To compare the safety and efficacy of domestic pantoprazole capsule with those of imported omeprazole capsule in treatment of reflux esophagitis.Methods:60 patients with reflux esophagitis were equally and randomly divided to receive domestic pantoprazole capsule 50mg twice daily for 8 weeks or imported omeprazole capsule 20mg twice daily for 8 weeks.Side effects were care observed during treatment and endoscopy was performed again after treatment.Results:The cure and effective rate for pantolazole group were 93.4% and 6.6% respectively;for omeprazole group were 83.3% and 16.7% respectively.The endoscopic cure and effective rate for pantolazole group were 90.1% and 6.6% respectively and for omeprazole group were 86.7% and 10.0% respectively.Conclusion:The safety and efficacy of domestic pantoprazole capsule are comparable to those of imported omeprazole capsule in treatment of reflux esophagitis.