| 红霉素收缩金黄地鼠胆囊的研究 |
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| 引用本文： | 傅德良,张延龄.红霉素收缩金黄地鼠胆囊的研究[J].中华实验外科杂志,1995,12(6):350-351. |
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| 作者姓名： | 傅德良 张延龄 |
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| 作者单位： | 上海医科大学华山医院外科，上海医科大学基础学院 |
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| 摘 要： | 通过离体试验观察红霉素对金黄地鼠胆囊运动的影响，结果发现红霉素可以使正常组和致石组胆囊产生剂量依赖性收缩，而且发现在胆囊结石形成前后红霉素的作用同样存在，红霉素收缩金黄地鼠胆囊的作用可能是通过激活胃动素受体介导的，这一发现有助于胆囊运动能障碍的治疗。
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| 关 键 词： | 红霉素 胆结石 胆囊运动 |
Experimental study on effect of ery-thromycin on motility of gallbladder in goldenhamsters |
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| Fu De-liang,zhang Yan-ling,WangZheng-yu,et al..Experimental study on effect of ery-thromycin on motility of gallbladder in goldenhamsters[J].Chinese Journal of Experimental Surgery,1995,12(6):350-351. |
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| Authors: | Fu De-liang zhang Yan-ling WangZheng-yu |
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| Institution: | Fu De-liang,zhang Yan-ling,WangZheng-yu,et al. Department of Surger,Huashan
Hospital,Shanghai Medical Univer-sity,Shanghai 200040. |
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| Abstract: | Effect of erythromycin on
motility of gall-bladder in golden hamsters were studied in vit-ro. It was found that erythromycin
could induce concentration-dependent contraction ofgallbladder of animals fed with normal
andlithogenic diet and that there was no signifi-cant difference between normal group
andlithogenic group before or after formation ofgallstone. The effect of erythromycin on motil-ity
may be mediated by activation of motilinreceptors on the surface of gallbladder
smoothmuscles. It is recommended to use ery-thromycin in the treatment of gallbladder
hy-pomotility. |
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| Keywords: | erythromycin gallbladderstone gallbladder motility |
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