应用激素等药后口腔、咽部真菌带菌情况的观察报告

对552例住院皮肤病人作了口腔、咽部分泌物的真菌培养.结果阳性72例.其中接受皮质类固醇、免疫抑制剂或抗生素治疗的226例中培养阳性64例,占28.3%;而未经激素、免疫抑制剂或抗生素治疗的326例中.培养阳性8例.占2.5%,两者有极显著差异.分离出的菌株主要是白色念珠菌,其次是酵母菌、黄曲菌、克柔氏念珠菌等.培养阳性的72例中,有25例最后出现轻重不一的条件性真菌病.他们都是接受皮质类固醇、免疫抑制剂或抗生素治疗的病人,以鹅口疮占多数(19例),较为严重的肺炎有4例,均为结缔组织病、天疤疮等长期应用激素、免疫抑制剂或抗生素的患者.调查结果表明,长期应用激素、免疫抑制剂或抗生素治疗的病例,密切观察其口咽部真菌的生长动态,有助于早期发现条件性真菌病.

Observation on carrping rate of fungus in oral and pharyngeal secretion from in patients after treatment of corticosteroids etc.

Oral and pharyngeal secretion from 552 in-patients with dermatoses was cultured for fungous growth,72 cases showed a positive result.Among them,64 cases were in the group of 226 cases being treated with corticosteroids,immunosuppressants or antibiotics(28.3%),and only 8 cases were is the group of 326 cases with no treatment of corticosteroids,immunosuppressants or aatibiotics(2.5%).There was a significant difference between these two groups statistically.