乙型肝炎后肝硬化患者血小板参数的临床分析

目的 观察血小板参数变化与乙型肝炎后肝硬化的关系并探讨其临床意义。方法 乙型肝炎后肝硬化患者135例（A组）和健康体检者82例（B组）采用全自动血细胞分析仪检PLT、血小板比容（PCT）、平均血小板体积（MPV）、血小板分布宽度（PDW）。A组患者根据有无上消化道出血分为合并上消化道出血组（C组,65例）和无上消化道出血组（D组,70例）,分别比较各组参数情况。结果 A组PLT、PCT均显著低于B组（P均=0.006）,其MPV、PDW均高于B组（P均=0.007）。C组PLT、PCT、MPV、PDW均低于D组（P均〈0.05）。结论 血小板参数的测定对评估肝硬化患者肝功能损害程度、判断有无出血倾向具有重要的指导意义。

Clinical analysis on platelet parameters of patients with hepatitis B cirrhosis

Objective To explore the clinical significance of the relationship between the change of platelet parameters and liver cirrhosis after hepatitis B. Methods Total of 135 cases with liver cirrhosis after hepatitis B （group A） and 82 cases with healthy physical examination （group B） were detected for platelet count （PLT）, thrombocytocrit （PCT）, mean platelet volume （MPV）, platelet distribution width （PDW）. According to gastrointestinal bleeding, the patients were divided into group A combination of upper gastrointestinal hemorrhage group （group C, 65 cases） and supreme gastrointestinal bleeding group （group D, 70 cases）, each parameter were compared. Results PLT, PCT of group A were significantly lower than that of group B （P = 0.006）, its MPV and PDW were higher than that of group B （P = 0.007）. PLT, PCT, MPV and PDW of group C were lower than that of group D （both P 〈 0.05）. Conclusions Determination ofplatelet parameter to assess liver function damage in patients with cirrhosis, determine presence of bleeding tendency has important guiding significance.