| 苯丙醇胺控释混悬剂在健康志愿者的生物利用度 |
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| 引用本文： | 陈秋潮,陈伟力,戴幼琴,葛国庆,林德昌.苯丙醇胺控释混悬剂在健康志愿者的生物利用度[J].药学学报,1992,27(4):299-302. |
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| 作者姓名： | 陈秋潮 陈伟力 戴幼琴 葛国庆 林德昌 |
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| 作者单位： | 上海医科大学附属中山医院临床药理室，上海医科大学附属中山医院临床药理室，宁波市第二人民医院，上海延安制药厂制剂研究室，上海延安制药厂制剂研究室 上海 200032，上海 200032，进修生，上海 200050，上海 200050 |
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| 摘 要： | 研究建立了HPLC测定苯丙醇胺(PPA)体内血药浓度的方法,比较了10名正常受试者单剂量口服苯丙醇胺控释混悬剂(含PPA 150mg)与等剂量的普通PPA片的生物利用度,结果两者AU0～∞无显著性差异P>0.4,相对生物利用度F=102.6%。
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| 关 键 词： | 苯丙醇胺 控释混悬剂 高效液相色谱法 生物利用度 |
| 收稿时间： | 1990-09-29 |
BIOAVAILABILITY OF A CONTROLLED-RELEASE SUSPENSION OF PHENYLPROPANOLAMINE IN HEALTHY VOLUNTEERS |
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| QC Chen,WL Chen,YQ Dai,GQ Ge,DC Lin Zhongshan.BIOAVAILABILITY OF A CONTROLLED-RELEASE SUSPENSION OF PHENYLPROPANOLAMINE IN HEALTHY VOLUNTEERS[J].Acta Pharmaceutica Sinica,1992,27(4):299-302. |
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| Authors: | QC Chen WL Chen YQ Dai GQ Ge DC Lin Zhongshan |
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| Institution: | Zhongshan Hospital, Shanghai Medical University. |
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| Abstract: | A high-performance liquid chromatographic analysis of phenylpropanolamine (PPA) in human plasma is presented. Using direct UV detection the method is sufficiently sensitive to 25 ng/ml for PPA. Single-dose pharmacokinetics of PPA in 10 healthy volunteers taking controlled release suspension (C) or tablet (T), each containing 150 mg PPA was compared. The study described here has shown that the (C) AUC(0-infinity)/(T) AUC(0-infinity) = 1.02 (P greater than 0.4). The controlled-release product of PPA is equivalent to PPA tablet. |
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| Keywords: | Phenylpropanolamine Controlled--release suspesion HPLC Bioavailability |
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