| 易卒中型肾血管性高血压大鼠血浆CAM-1和P-选择素的动态观察 |
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| 引用本文： | 杨弘文,聂亚雄,姜波涛,霍瑞民,张平,王东. 易卒中型肾血管性高血压大鼠血浆CAM-1和P-选择素的动态观察[J]. 神经疾病与精神卫生, 2008, 8(2): 126-128 |
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| 作者姓名： | 杨弘文 聂亚雄 姜波涛 霍瑞民 张平 王东 |
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| 作者单位： | 421001,南华大学附属第一医院神经内科;421001,南华大学附属第一医院神经内科;421001,南华大学附属第一医院神经内科;421001,南华大学附属第一医院神经内科;421001,南华大学附属第一医院神经内科;421001,南华大学附属第一医院神经内科 |
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| 摘 要： | 目的动态观察易卒中型肾血管性高血压大鼠（RHRSP）血浆ICAM-1和P-选择素的活性改变。方法双肾双夹法制作RHRSP模型,分别于术前及术后2、4、6、8、10、12、16周取血,酶联免疫吸附测定（ELISA）法检测ICAM-1和P-选择素含量。结果4周始RHRSP血中ICAM-1和P-选择素含量逐渐增高,明显高于正常对照组,且ICAM-1和P-选择素呈正相关,ICAM-1和P-选择素均与大鼠收缩压密切相关。结论血浆中ICAM-1和P-选择素含量升高提示梗死或出血的危险性增加,可作为脑卒中的预测指标之一。
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| 关 键 词： | 脑卒中 高血压 粘附分子 选择素 |
| 文章编号： | 1009-6574(2008)02-0126-03 |
| 修稿时间： | 2008-01-09 |
The ICAM-1 and P-selectin levels change in stroke-prone renovascular hypertensive rats |
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| YANG Hong-wen,NIE Ya-xiong,JIANG Bo-tao,et al.. The ICAM-1 and P-selectin levels change in stroke-prone renovascular hypertensive rats[J]. Nervous Diseases and Mental Health, 2008, 8(2): 126-128 |
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| Authors: | YANG Hong-wen NIE Ya-xiong JIANG Bo-tao et al. |
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| Affiliation: | YANG Hong-wen,NIE Ya-xiong,JIANG Bo-tao,et al. Department of Neurology,1st Affiliated Hospital of NanHua University,Hengyang 421001,China |
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| Abstract: | Objective To study the ICAM-1 and P-selectin levels change in stroke-prone renovascular hypertensive rats (RHRSP).Methods Two-kidney-two-clip RHRSP were used in the present study. The levels of ICAM-1 and P-selectin were measured by enzyme-linked immunosorbant assay (ELISA) at pre-operation, and 2w, 4w, 8w, 12w and 16w after operation.Results Levels of ICAM-1 and P-selectin in the rats from 4w to 16w after operation were increased markedly compared with control group. Correlation analysis showed that blood pressure, ICAM-1 and P-selectin level correlated closely with each other.Conclusions Up-regulative activity of ICAM-1 and P-selectin may play a role in the onset of cerebral infarction, cerebral hemorrhage, it may be as an indicator of mixed stroke. |
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| Keywords: | Cerebral apoplexy Hypertension Cell adhesion molecules Selectin |
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