Churg-Strauss syndrome and the leukotriene receptor antagonist pranlukast |
| |
Authors: | Junsuke Shimbo Osamu Onodera Keiko Tanaka Shoji Tsuji |
| |
Affiliation: | (1) Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute, Niigata University, 1-757 Asahimachi, Niigata 951-8520, Japan;(2) Department of Neurology, University of Tokyo, Tokyo, Japan |
| |
Abstract: | The authors studied eight cases of Churg-Strauss syndrome (CSS) associated with the use of pranlukast, a common cysteinyl leukotriene receptor antagonist (LTRA) in Japan. The patients who received pranlukast showed significantly increased peripheral blood eosinophil count, neurological disability scores, and poor responses to corticosteroid in comparison with those patients not receiving pranlukast. We suggest that preceding administration of pranlukast aggravates clinical presentations of CSS. |
| |
Keywords: | Churg-Strauss syndrome Leukotriene receptor antagonists Pranlukast |
本文献已被 PubMed SpringerLink 等数据库收录! |
|