TCR1+ large granular lymphocyte proliferation in rheumatoid arthritis |
| |
Authors: | J G Kuipers R Jacobs A Kemper H Zeidler R E Schmidt |
| |
Institution: | (1) Department of Clinical Immunology, Hannover Medical School, Konstanty-Gutschow-Strasse 8, D-30625 Hannover, Germany;(2) Department of Rheumatology, Hannover Medical School, Hannover, Germany |
| |
Abstract: | The T -lymphoproliferative syndrome is characterized by a proliferation of large granular lymphocytes (LGL). It is often associated with neutropenia, and in 30% of cases with rheumatoid arthritis (RA). Phenotypic analysis has demonstrated that in most cases of RA with T -proliferative disease, the LGL represent T cells with a clonal rearrangement of the / T cell receptor (TCR2). Here, three patients with / TCR1+ LGL proliferation suffering from long-standing arthritis and neutropenia are described. The first patient with RA showed an expansion of a heterogeneous CD2+ CD16+ CD56- LGL population, of which 30% coexpressed TCR1 with V 1 rearrangement. The second patient with ankylosing spondylitis and RA was suffering from proliferation of TCR1+ (V 9-, V 1-), CD2+ CD16- CD56- LGL with low coexpression of CD8. The third patient with RA was suffering from a proliferation of TCR1+ (V 1+, V 9-) CD4- CE8- CD16- CD56- lymphocytes. On the basis of these unusual findings, the pathogenetic role of TCR1+ T cells in RA is discussed. |
| |
Keywords: | T -lymphoproliferative syndrome" target="_blank">gif" alt="gamma" align="MIDDLE" BORDER="0">-lymphoproliferative syndrome Large granular lymphocytes Rheumatoid arthritis / gif" alt="agr" align="BASELINE" BORDER="0">/ T cell receptor (TCR2)" target="_blank">gif" alt="beta" align="MIDDLE" BORDER="0"> T cell receptor (TCR2) / gif" alt="gamma" align="MIDDLE" BORDER="0">/ TCR1+" target="_blank">gif" alt="delta" align="BASELINE" BORDER="0"> TCR1+ |
本文献已被 SpringerLink 等数据库收录! |
|