Antiviral activity of an extract of Cordia salicifolia on herpes simplex virus type 1 |
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| Authors: | K Hayashi T Hayashi N Morita S Niwayama |
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| Institution: | Department of Virology, Toyama Medical and Pharmaceutical University, Toyama, Japan. |
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| Abstract: | A partially purified extract (COL 1-6) from whole plant of Cordia salicifolia showed an inhibitory effect on herpes simplex virus type 1 (HSV-1). The activity of COL 1-6 on different steps of HSV-1 replication in HeLa cells was investigated. Under single-cycle replication conditions, COL 1-6 exerted a greater than 99.9% inhibition in virus yield when added to the cells 3 h or 1.5 h before infection, and even when added 8 h after infection the extract still caused a greater than 99% inhibition. The extract has been shown to have a direct virucidal activity. And also, analysis of early events following infection showed that COL 1-6 affected viral penetration in HeLa cells but did not interfere with adsorption to the cells. |
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