| rhG-CSF对Ara-C杀伤急性髓性白血病细胞影响的实验研究 |
| |
| 引用本文： | 张学忠,王秀华.rhG-CSF对Ara-C杀伤急性髓性白血病细胞影响的实验研究[J].白血病．淋巴瘤,1999(1). |
| |
| 作者姓名： | 张学忠 王秀华 |
| |
| 作者单位： | 南京医科大学附属南京第一医院 |
| |
| 摘 要： | 目的探讨ｒｈＧ－ＣＳＦ对２１例急性髓性白血病（ＡＭＬ）细胞体外对阿糖胞苷（Ａｒａ－Ｃ）敏感性的影响。方法采用ＭＴＴ法检测Ａｒａ－Ｃ的细胞毒作用。结果ｒｈＧ－ＣＳＦ可显著增强Ａｒａ－Ｃ对耐药ＡＭＬ细胞的毒性，与对照组相比Ｐ＜０．０５；结论ｒｈＧ－ＣＳＦ可能通过促进耐药ＡＭＬ细胞进入增殖周期，而增强Ａｒａ－Ｃ对耐药ＡＭＬ细胞的毒性，从而具有耐药的逆转效应，预示着ｒｈＧ－ＣＳＦ与Ａｒａ－Ｃ联合运用治疗耐药ＡＭＬ的潜在价值
|
| 关 键 词： | 重组人粒系集落刺激因子 白血病 髓细胞性 阿糖胞苷 |
EXPERIMENTAL STUDY OF RECOMBINANT HUMAN GRANULOCYTE COLONY STIMULATING FACTOR ENHANCING CYTOSINE ARABINOSIDE AGAINST ACUTE MYELOID LEUKEMIA CELLS |
| |
| Zhang Xuezhong,Wang Xiaohua Nanjing first Hospital,Nanjing Medical University,.EXPERIMENTAL STUDY OF RECOMBINANT HUMAN GRANULOCYTE COLONY STIMULATING FACTOR ENHANCING CYTOSINE ARABINOSIDE AGAINST ACUTE MYELOID LEUKEMIA CELLS[J].Journal of Leukemia & Lymphoma,1999(1). |
| |
| Authors: | Zhang Xuezhong Wang Xiaohua Nanjing first Hospital Nanjing Medical University |
| |
| Abstract: | Objective The effect of recombinant human granulocyte colony stimulating factor(rhG CSF)on the sensitivity of acute myeloid leukemia(AML) cells to cytosine arabinoside(Ara C)in vitro was studied in twenty one patients.Methods Cytotoxicity of Ara C was detected by the MTT assay.Result rhG CSF significantly enhanced the cytotoxic activity of Ara C to druy resistant AML cells compared with control group ( P <0 05).Conclusion It suggests that rhG CSF may enhance the sensitivity of drug resitant AML cells to Ara C in vitro by recruiting blasts into the cell cycle.There for , its use in treating AML Patients of drug resistance with rhG CSF and Ara C was recommended. |
| |
| Keywords: | rhG CSF Leukemia Actute myeloid Ara C |
| 本文献已被 CNKI 等数据库收录！ |
