Isaacs综合征1例报道和文献复习

目的：探讨Isaacs综合征的发病机制、临床特征、诊断和治疗。方法：回顾性分析中国医科大学附属第一医院神经内科收治的1例Isaacs综合征患者的临床表现、辅助检查、治疗和预后,结合文献进行分析。结果：患者男性,71岁。主要表现为自发性肌肉颤搐,睡眠时症状不消失。肌电图可见颤搐电位和轻度运动神经传导速度减慢。卡马西平治疗后症状控制良好。结论：Isaacs综合征是一种自身免疫性疾病,病因尚不明确,肌肉颤搐及典型肌电图表现是诊断关键,卡马西平和苯妥英钠为首选治疗药物。

A Case Report and Literature Review of Isaacs' Syndrome

To evaluate the pathogenesis, characteristics, diagnosis and therapy of Isaacs’ syndrome. Methods： Clinical data, laboratory examination, treatment and prognosis of one case with Isaacs’ syndrome were analyzed retrospectively while making a literature review. Results： This case was a 71 year old man with spontaneous myokymia that didn’t disappear during sleeping. Electromyography showed twitch potential and slow motor nerve conduction velocity. Carbamazepine could relieve the most clinical characteristics. Conclusion： Isaacs’ syndrome is an autoimmune disease that the etiology remains unclear. The diagnosis of Isaacs’ syndrome mainly depends on clinical features of myokymia and the changes of electromyography. Carbamazepine or phenytoin is a preferred drug for Isaacs’ syndrome.