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Effects of inactivated influenza vaccine on postvaccination immunity against tuberculosis
Authors:G N Kalmykova  I K Dorofeeva
Abstract:The importance of inactivated influenza virus vaccines (IIVV) as a risk factor leading to a change of immunologic reactivity in persons earlier revaccinated with BCG once, twice or thrice was studied. The condition of T system was investigated by blast-transformation reaction with PPD-L and PHA in 1 and 3 months after administration of different types of IIVV. If all types of IIVV are administered, there is an inhibition of a specific activity of T cells with a certain stimulation of their nonspecific functions. The intensity of IIVV impact depends on the type, number, and duration of prior BCG vaccinations, as well as the initial condition of T-link.
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