免疫比浊法检测高脂血症患者血清Apo-E的临床意义

目的 探讨高脂血症(Hyperlipidemia,HLP)患者血清apoE水平测定的临床意义.方法 用免疫比浊法检测120例HLP患者和130例健康成人血清Apo-E及TC、HDL-C、LDL-C、TG、ApoA1、apoB.结果 HLP患者血清apoE水平明显高于正常对照组(55.2±14.3mg/L,40.4±12.5mg/L;P＜0.01),且与TG、Apo-B呈显著正相关(r=0.538,0.432;P＜0.05),是冠心病(Coronary heart disease,CHD)和动脉粥样硬化(Atheroselerosis,AS)的危险因子.结论 HLP患者血清apoE水平明显升高,检测血清apoE水平可作为心脑血管疾病的辅助诊断指标.

The clinical significance of serum Apo-E detected by immunoturbidimetric assay on patients with hyperlipidemia

Objective To discuss the clinical significance of the detection of serum Apo-E level of patients with hyperlipidemia (HLP).Methods The serum Apo-E,TC,HDL-C,LDL-C,TG,Apo-Al and Apo-B in 120 patients with HLP and 130 health adults were detected by immunoturbidimetry.Results The serum Apo-E level in patients with HLP was significantly higher than that in normal group (55.2 ± 14.3mg/L,40.4 ± 12.5mg /L;P ＜0.01 ),and was significant positive correlated with the TG and Apo-B (r=0.538,0.432;P＜0.05).The Apo-E level was a risk factor of coronary heart disease and atherosclerosis.Conclusions The serum Apo-E levels in patients with HLP were significant increased.The detection of serum Apo-E level can be used as a diagnosis index of cardio-cerebral vascular disease.