Antiglutamic Acid Decarboxylase Antibodies in Children With Encephalitis and Status Epilepticus |
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Authors: | Jainn-Jim Lin Kuang-Lin Lin Shao-Hsuan Hsia Huei-Shyong Wang I-Jun Chou Yun-Tong Lin;CHEESE Study Group |
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Institution: | Division of Pediatric Neurology, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Division of Pediatric Critical Care and Division of Emergency Medicine, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Chang Gung Children's Hospital Study Group for Children With Encephalitis/Encephalopathy Related Status Epilepticus and Epilepsy (CHEESE), Chang Gung Children's Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan. |
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Abstract: | Encephalitis may present with seizures or status epilepticus, and the etiology is usually presumed. Specific antibodies to ion channels, receptors, and other synaptic proteins were identified during the past decade. However, only a few studies investigated antiglutamic acid decarboxylase antibodies and antibodies to cell membrane ion channels or surface antigens in pediatric encephalitis and status epilepticus. We examined antibodies to glutamic acid decarboxylase and cell membrane ion channels or surface antigens in acute-phase serum from 17 children with encephalitis and status epilepticus. Antiglutamic acid decarboxylase antibody titers were compared with those of control children manifesting therapy-resistant epilepsy. Antiglutamic acid decarboxylase antibody titers were significantly higher in those with encephalitis and status epilepticus than in those with therapy-resistant epilepsy. No patient demonstrated antibodies to cell membrane ion channels or surface antigens. Six children exhibited positive antiglutamic acid decarboxylase antibodies. One child died, three manifested postencephalitic epilepsy with neurologic deficits, and two recovered well. Higher antiglutamic acid decarboxylase antibody titers were evident in the children with encephalitis and status epilepticus. Clinicians should be aware of the potential role of antiglutamic acid decarboxylase antibodies in children with encephalitis and status epilepticus. |
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