Influence of lung parenchymal destruction on the different indexes of the methacholine dose-response curve in COPD patients |
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| Authors: | Verhoeven G T Verbraak A F Boere-van der Straat S Hoogsteden H C Bogaard J M |
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| Institution: | Department of Pulmonary and Intensive Care Medicine, University Hospital Dijkzigt, Erasmus Medical Center, Rotterdam, The Netherlands. Verhoeven@lond.azr.nl |
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| Abstract: | STUDY OBJECTIVES: The interpretation of nonspecific bronchial provocation dose-response curves in COPD is still a matter of debate. Bronchial hyperresponsiveness (BHR) in patients with COPD could be influenced by the destruction of the parenchyma and the augmented mechanical behavior of the lung. Therefore, we studied the interrelationships between indexes of BHR, on the one hand, and markers of lung parenchymal destruction, on the other. PATIENTS AND METHODS: COPD patients were selected by clinical symptoms, evidence of chronic, nonreversible airways obstruction, and BHR, which was defined as a provocative dose of a substance (histamine) causing a 20% fall in FEV(1) (PC(20)) of
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