经皮射频毁损治疗肝癌监测可溶性肿瘤坏死因子受体Ⅰ,Ⅱ的临床意义

目的探讨可溶性肿瘤坏死因子受体检测在超声引导下经皮射频毁损(RFA)治疗原发性肝癌(HCC)的临床意义。方法采用RF2000型射频治疗仪,在B超引导下经皮RFA治疗30例HCC患者。采用双抗体夹心酶联免疫法(ELISA),检测患者RFA治疗前后血清sTNFRⅠ,sTNFRⅡ水平的改变,并检测25例HCC血清sTNFRⅠ,sTNFRⅡ与健康对照组比较。结果HCC患者RFA治疗后血清sTNFRⅠ,sTNFRⅡ水平较治疗前水平显著降低(P<0.05);HCC与对照组比较有非常显著性差异(P<0.01)。结论检测HCC患者血清sTNFRⅠ,sTNFRⅡ的水平,有助于了解患者的免疫状况,RFA治疗能有效减轻瘤负荷,改善患者机体免疫功能。

Changes of Serum Soluble Tumor Necrosis Factor Receptors in Patients with Hepatocellular Cancer after Percutaneous Radiofrequency Ablation Treatment

Objective To investigate the c hanges of serum soluble tumor necrosis factor receptors (sTNFRs) in the patients with hepatocellular carcinoma (HCC) before and after percutaneous radiofrequenc y ablation (RFA) treatment and evaluate their significance. Methods Thirty HCC patients were treated by electrodes inserted to the foci percutaneously under ultrasound guidance using RF2000 generator. Th e levels of serum sTNFR Ⅰand Ⅱ were detected before and after RFA by ELISA. Results After RFA, sTNFRⅠ and Ⅱ declined significantly (P <0.05). Conclusion Examinations of sTNFR Ⅰ and Ⅱ are helpful to knowi ng the immune state. The method of RFA can improve immune function of the patien ts with HCC.