恶性肿瘤患者血清PA、TSGF检测及其临床意义

目的:探讨血清前清蛋白(prealbumin,PA)和肿瘤特异性生长因子(tumor specific growth factor,TSGF)对恶性肿瘤的诊断价值。方法:采用免疫比浊法和化学法分别检测169例恶性肿瘤患者、24例良性肿瘤患者血清PA、TSGF,并以30名健康体检者作对照。结果:良性肿瘤组血清PA高于健康对照组(P<0.01),而TSGF与健康对照组差异无统计学意义(P>0.05);恶性肿瘤组血清PA (除肾癌患者外)与健康对照组比较均显著降低(P<0.01),TSGF均显著升高(P<0.01)。PA阳性率为72.19%,特异性为93.33%;TSGF阳性率为62.13%,特异性为86.67%;二者联合检测阳性率为79.88%。结论:恶性肿瘤患者血清PA、TSGF含量变化明显,联合检测有助于提高恶性肿瘤诊断的符合率。

Detection of the serum prealbumin and tumor specific growth factor in cancerous patients and its clinical significance

Objective：To study the value of serum prealbumin（PA） and tumor specific growth factor（TSGF） in diagnosis of malignant tumor. Methods：By using the immunoturbidimetry and chemical method the serum PA and TSGF were determined in 169 cancerous patients, and 24 benign tumor patients, and 30 healthy subjects. Results：The serum P？/was apparently higher in benign tumor group than that of the health normal group（ P 〈 0.01 ）, but TSGF had no difference （ P 〉 O. 05 ） ; In cancerous group （ besides kidney cancer patients ） the serum PA was all significantly lower（ P 〈 0. 01 ）, TSGF was all significantly higher（ P 〈 0.01 ） comparing with the healthy comparison group. The positive rate of the PA was 72.19% ,the specificity was 93.33% ;the positive rate of the TSGF was 62.13% ,the specificity was 86.67% ;the positive rate of two union detection was 79.88%. Conclusions：The serum PA ,TSGF of cancerous patients obviously changes, the union detection is helpful to improve diagnostic coincidence rate of cancer.