A model for investigating the effect of drugs on the peripheral sympathetic nervous system in man |
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| Affiliation: | 1. Department of Pharmaceutical Sciences, Dr. H.S. Gour University, Sagar, M.P. 470002, India;2. Pharmacy College, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, U.P. 206130, India;3. Community Medicine, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, U.P. 206130, India;1. Department of Environmental Chemistry, Faculty of Chemistry, University of Łódź, Łódź, Poland;2. Chair of Medical Biochemistry, Jagiellonian University, Medical College, Kraków, Poland;3. Fressenius Nephrocare, Rydygier Hospital, Kraków, Poland;1. Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, Netherlands;2. Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, Netherlands;3. Department of Clinical Genetics, Leiden University Medical Centre, Leiden, Netherlands;4. Division Laboratories, Pharmacy and Biomedical Genetics, Hospital Pharmacy, University Medical Centre Utrecht, Utrecht, Netherlands;5. Centre for Medical Statistics, Informatics and Intelligent Systems, Institute of Artificial Intelligence, Medical University of Vienna, Vienna, Austria;6. Pharmacogenetics Laboratory, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia;7. CNRS, Centre for Epidemiology and Research in Population health (CERPOP), Université de Toulouse, Inserm, UPS, Toulouse, France;8. Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy;9. Medicines Information Centre, Royal Dutch Pharmacists Association (KNMP), The Hague, Netherlands;10. Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Netherlands;11. Service de pharmacologie médicale et clinique, CEIP-addictovigilance de Toulouse, faculté de médecine, CHU, Toulouse, France;12. Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, Stockholm, Sweden;13. Department of Pharmacy, Uppsala University, Uppsala, Sweden;14. Department of Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria;15. Institute of Clinical Pharmacology, University Hospital RWTH Aachen, Aachen, Germany;p. Bio.logis Digital Health, Frankfurt am Main, Germany;q. Diagnosticum Centre for Humangenetics, Frankfurt am Main, Germany;r. Clinical Pharmacy, Saarland University, Saarbrücken, Germany;s. The Golden Helix Foundation, London, UK;t. Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, Abu Dhabi, United Arab Emirates;u. Zayed Centre for Health Sciences, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, Abu Dhabi, United Arab Emirates;v. Universite de Toulouse III Paul Sabatier, Toulouse, France;w. Department of Pharmacology and Therapeutics, Wolfson Centre for Personalised Medicine, The University of Liverpool, Liverpool, UK;x. Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany;y. iFIT Cluster of Excellence (EXC2180)—Image Guided and Functionally Instructed Tumour Therapies, University of Tuebingen, Tuebingen, Germany;z. Department of Clinical Pharmacology, University of Tuebingen, Tuebingen, Germany;11. Department of Pharmacy and Biochemistry, University of Tuebingen, Tuebingen, Germany;12. University of Patras School of Health Sciences, Department of Pharmacy, Division of Pharmacology and Biosciences, Laboratory of Pharmacogenomics and Individualised Therapy, Patras, Greece;13. Clinical Pharmacy Department, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Biosanitaria Granada, Granada, Spain;14. Erasmus University Medical Centre, Faculty of Medicine and Health Sciences, Department of Pathology—Clinical Bioinformatics Unit, Rotterdam, Netherlands;1. Department of Biological Sciences, Birla Institute of Technology and Science, Pilani-Hyderabad Campus, Hyderabad, 500 078, India;2. Department of Chemistry, Birla Institute of Technology and Science, Pilani-Hyderabad Campus, Hyderabad, 500 078, India |
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| Abstract: | A model for assessing the effect of sympatholytic drugs on the peripheral sympathetic nervous system in man is described. Guanethidine, a sympatholytic drug, and the vehicle have been used to explore the model which is based on the Bier block. Sympathetic activity was assessed by measuring: (i) palmar sweating; (ii) skin temperature; (iii) radial/brachial pressure index; (iv) hand blood flow; and (v) vasoconstrictor ice response of hand blood flow. Neither the tourniquet nor the vehicle had any effect on sympathetic activity whereas guanethidine produced significant changes in skin temperature (P < 0.05), hand blood flow (P < 0.001) and the vasoconstrictor ice response (P < 0.002), illustrating the usefulness of the model. |
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