复方BMP治疗骨折的动物实验及临床观察

本文报告以BMP制剂治疗骨折的动物实验及临床应用。66只家兔分三组,在桡骨中部造成横形骨折。Ⅰ和Ⅱ组骨折部分别注入复方普鲁卡因BMP及单纯普鲁卡因BMP,Ⅲ组为对照,不注入药物。术后X线照片、组织学。骨痂钙含量及生物力学测试均表明复方BMP的疗效最佳,在实验基础上以复方BMP治疗成人胫腓骨骨折18例。经追踪观察,伤后3个月内均已愈合,病人未出现明显的全身和局部反应。本研究为骨形态形成蛋白用于临床骨折治疗迈出重要的一步。

Experimental and clinical observations on treatment of fracture with compound BMP

Animal experiment and clinical application of BMP preparation for fracture treatment are reported. 66 rabbits, all with a transverse fracture at the middle of the radius, were divided into 3 groups. Group 1 was treated with local injection of a compound of 25mg partially purified swine BMP and other drugs including vitamin C, B1 , calcium gluconate and 1 % procaine. Group 2 was treated with same amount of BMP in 0.4ml 1 % procaine in the same manner. Group 3 was a control being given no specific treatment. Postoperative observations by serial X-ray films, histological sections, callus calcium content estimations and biomechanical tests have shown that best results were obtained in group 1 animals treated with the compound BMP. Clinical trials on 18 cases of fractures of lower middle third of the tibia and fibula were carried out. Two injections of compound BMP were given to each case at the early phase of fracture repair. Follow-up observations have proved prompt healing of all fractures within 3 months without any systemic or local untoward effects. This investigation should be regarded an important step for clinical use of BMP preparations to treat fractures supposed to be more difficult to unite.