| 醋酸棉酚对大鼠睾网液中K~+、Na~+及睾酮水平的影响 |
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| 引用本文： | 童建孙,祁爱平,王如,马建军,钱绍祯.醋酸棉酚对大鼠睾网液中K~+、Na~+及睾酮水平的影响[J].中国药理学通报,1987(5). |
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| 作者姓名： | 童建孙 祁爱平 王如 马建军 钱绍祯 |
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| 作者单位： | 江苏省计划生育研究所基础研究室 南京
(童建孙，祁爱平，王如，马建军)，江苏省计划生育研究所基础研究室 南京(钱绍祯) |
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| 摘 要： | 成年雄鼠给予15mg/kg/d醋酸棉酚,连续50d灌服,导致不育,精子生成与附睾精子活力都受到明显影响。但血清与睾网液中K~+、Na~+、睾酮水平与对照组相比无明显变化。因此认为给予较低剂量的醋酸棉酚灌服大鼠,可以阻断生精作用而达到抗生育效果,但并不影响K~+、Na~+与睾酮在睾丸中分泌与转运。
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| 关 键 词： | 醋酸棉酚 睾网液 睾酮 K~+ Na~+ |
THE EFFECT OF GOSSYPOL ON K~+, Na~+ AND TESTOSTERONE IN SERUM AND RAT TESTIS FLUID IN RATS |
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| Tong Jiansun,Qi Aiping,Wang Ru,Ma Jianjun,Qian Shaozhen.THE EFFECT OF GOSSYPOL ON K~+, Na~+ AND TESTOSTERONE IN SERUM AND RAT TESTIS FLUID IN RATS[J].Chinese Pharmacological Bulletin,1987(5). |
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| Authors: | Tong Jiansun Qi Aiping Wang Ru Ma Jianjun Qian Shaozhen |
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| Abstract: | Feeding adult male rats with gossypol acetic acid at a dose of 15 nig/kg/day for 50 days led to infertility. Spermatogenesis and sperm motility were impaired ( table 1 ) . However, testosterone, K+ and Na+ concentsrations in serum and RTF were found to be unchanged (table 2, 3 ) . It suggests that at low antifertility doses gossypol disrupts spermatogenesis in the seminiferous epithelium without affecting testosterone, K+ and Na+ secretion and translation in testis. |
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| Keywords: | acetic gossypol RTF ( rete testis fluid) K+ Na+ testosterone |
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