| 大鼠Walker-256肝微小转移癌模型的CT灌注成像研究 |
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| 引用本文： | 时高峰,王琦,许茜,李如迅,杜煜,王亚宁,李月考,杨丽,刘辉,彰俊杰,王士杰.大鼠Walker-256肝微小转移癌模型的CT灌注成像研究[J].中国医学影像技术,2006,22(1):35-38. |
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| 作者姓名： | 时高峰 王琦 许茜 李如迅 杜煜 王亚宁 李月考 杨丽 刘辉 彰俊杰 王士杰 |
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| 作者单位： | 河北医科大学第四医院CT室,河北,石家庄,050011 |
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| 基金项目： | 河北省科技厅资助项目(05276101D-67)。 |
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| 摘 要： | 目的通过多层螺旋CT灌注扫描研究肝脏微小转移癌大鼠的肝脏血流动力学变化。方法22只经脾脏注入Walker-256(细胞数量2×107)制备成肝脏微小转移癌的大鼠为实验组;10只大鼠经脾脏注入等量生理盐水为对照组。CT灌注扫描后用斜率法计算得到参数包括:肝动脉灌注量、门静脉灌注量、肝灌注指数、总肝灌注量。病理学检查HE染色证实转移癌的存在。结果19只大鼠发现的转移灶直径在0.5~6.6mm之间。肝脏微小转移癌的大鼠肝动脉的灌注量远远大于对照组(是对照组的2.25倍);而门静脉灌注量明显少于对照组(是对照组的76.6%)。总肝灌注量没有显著变化。结论大鼠微小肝转移癌表现为肝动脉灌注量的增加和门静脉灌注量的降低。CT灌注成像技术可以用来评价肝脏的血流动力学变化。
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| 关 键 词： | 转移性肝癌 灌注成像 体层摄影术 X线计算机 动物 实验 |
| 文章编号： | 1003-3289（2006）01-0035-04 |
| 收稿时间： | 2005-09-12 |
| 修稿时间： | 2005-11-07 |
CT perfusion imaging of Walker2256 small metastases in rat liver |
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| SHI Gao-feng,WANG Qi,XU Qian,LI Ru-xun,DU Yu,WANG Ya-ning,LI Yue-kao,YANG Li,LIU Hui,ZHANG Jun-jie and WANG Shi-j ie.CT perfusion imaging of Walker2256 small metastases in rat liver[J].Chinese Journal of Medical Imaging Technology,2006,22(1):35-38. |
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| Authors: | SHI Gao-feng WANG Qi XU Qian LI Ru-xun DU Yu WANG Ya-ning LI Yue-kao YANG Li LIU Hui ZHANG Jun-jie and WANG Shi-j ie |
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| Institution: | Department of Radiology,the Fourth Affiliated Hospital of Hebei Medical University,Shi jiazhuang 050011, China;Department of Radiology,the Fourth Affiliated Hospital of Hebei Medical University,Shi jiazhuang 050011, China;Department of Radiology,the Fourth Affiliated Hospital of Hebei Medical University,Shi jiazhuang 050011, China;Department of Radiology,the Fourth Affiliated Hospital of Hebei Medical University,Shi jiazhuang 050011, China;Department of Radiology,the Fourth Affiliated Hospital of Hebei Medical University,Shi jiazhuang 050011, China;Department of Radiology,the Fourth Affiliated Hospital of Hebei Medical University,Shi jiazhuang 050011, China;Department of Radiology,the Fourth Affiliated Hospital of Hebei Medical University,Shi jiazhuang 050011, China;Department of Radiology,the Fourth Affiliated Hospital of Hebei Medical University,Shi jiazhuang 050011, China;Department of Radiology,the Fourth Affiliated Hospital of Hebei Medical University,Shi jiazhuang 050011, China;Department of Radiology,the Fourth Affiliated Hospital of Hebei Medical University,Shi jiazhuang 050011, China;Department of Radiology,the Fourth Affiliated Hospital of Hebei Medical University,Shi jiazhuang 050011, China |
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| Abstract: | Objective To evaluate the hemodynamic changes of the liver caused by hepatic micrometastasies in rat s withmultislice computed tomography (CT) . Methods Liver micrometastases were produced in 22 SD rat s by t ransspleenic injec-ting 2 ×107 Walker2256 cells. Ten experimental cont rol rat s were injected with saline solution. The time-attenuation curvesof the aorta, portal vein , and the liver were used to calculate liver perfusion by gradient method designed for the dual bloodsupply.Results The micrometastases (diameter, between 0. 5 mm and 6. 6 mm) were seen in 19 rat s. Hepatic arterial per-fusion was 2. 25 times in the rat s with micrometastases than that in the cont rol rat s. Portal hepatic perfusion was 76. 6 %lower in the rat s with micrometastases than that in the cont rol rats. Total hepatic blood flow had no significant change.Con-clusion Liver micrometastases in rat s generate changes in liver perfusion that can be detected with CT. Small liver metasta-ses in rats canbe found decreasedlower the portal perfusion and higher increased the arterial perfusion. Perfusion CT tech-niques canbe used to evaluate the hemodynamic changes of the liver. |
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| Keywords: | Liver metastases Perfusion imaging Tomography X-ray computed Animals laboratory |
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