E—cadherin\FAK、13m23-H1蛋白表达与声门上型喉癌颈淋巴结转移的相关因素研究 |
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引用本文: | 张靖华,陈英武,平金良,徐炜,顾栋烨.E—cadherin\FAK、13m23-H1蛋白表达与声门上型喉癌颈淋巴结转移的相关因素研究[J].浙江医学,2011,33(8):1130-1132. |
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作者姓名: | 张靖华 陈英武 平金良 徐炜 顾栋烨 |
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作者单位: | 1. 湖州市中心医院耳鼻咽喉科,313000 2. 湖州市中心医院病理科,313000 |
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基金项目: | 湖州市自然科学基金项目 |
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摘 要: | 目的探讨E—cadherin、FAK、nm23-H1蛋白表达与声门上型喉癌颈淋巴结转移的关系,以利于临床上预估颈淋巴结转移情况。方法采用免疫组织化学Envision两步法检测70例声门上型喉癌中E—cadherin、FAK、nm23-H1的表达情况,结合患者临床资料分析3种免疫标志物(E—cadherin、FAK、nm23-H1蛋白)与颈淋巴结转移的相关性。结果E—cadherin及FAK蛋白表达与颈淋巴结转移均明显相关(P〈0.05)。nm23-H1蛋白表达与颈淋巴结转移无明显相关(P〉0.05)。E—cadherin及FAK蛋白均阳性表达与颈淋巴结转移显著相关(P〈0.01)。肿瘤分期、远处转移、病理分化程度均与颈淋巴结转移相关(均P〈0.01)。原发肿瘤分期T、组织分化G、FAK被纳入Logistic回归方程,利用该方程可得颈淋巴结无转移的准确率为75.6%.颈淋巴结有转移的准确率为82-7%,总体准确率为79.4%。结论声门上型喉癌转移与否与E—cadherin、FAK表达相关。与nm23-H1表达无明显相关,利用组织分化程度G、原发肿瘤分期T及FAK可以获得较高颈淋巴结转移的预计概率。
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关 键 词: | E-cadherin蛋白 FAK蛋白 nm23-H1蛋白 声门上型喉癌颈淋巴结转移 |
Expression of E-cadherin, FAK and nm23-H1 proteins in carcinoma of supraglottic larynx with lymph node metastasis |
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Institution: | ZHANG Jinghua, CHEN Yingwu, PING Jinliang, et al(Department of Otorhinolaryngology, Huzhou Central Hospital, Huzhou 313000,China) |
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Abstract: | Objective To investigate the expression of E-cadherin, FAK (Focal Adhesion Kinase) and nm23-H1 proteins in carcinoma of supraglottic larynx with cervical lymph node metastasis. Methods Expression of E-cadherin, FAK and nm23-H1 proteins were detected by Envision two-step immunohistochemical method in 70 cases of supraglottic laryngeal carcinoma. The relationship of E-cadherin, FAK and nm23-H1 expression with cervical lymph node metastasis was analyzed. Results E-cadherin and FAK were significantly correlated with cervical lymph node metastasis in supraglottic laryngeal cancer, but Nm23-H1 was not. Logistic regression showed that the diagnostic accuracy of combination of FAK expression, histological grade and T classification for cervical lymph node metastasis was 79.4%. Conclusions E-cadherin, FAK expression is significantly correlated with cervical node metastasis of supraglottic carcinoma. Combination with tissue differentiation G, primary tumor staging T and FAK expression can predict cervical lymph node metastasis with high accuracy. |
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Keywords: | E-cadherin protein FAK protein nm23-H1 protein Cervical lymph node metastasis Carcinoma ofsupraglottic larynx |
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