Utility of 128-row multidetector CT in quantitative evaluation of global left ventricular function in patients with coronary artery disease

Purpose

Is to compare the role of 128 MDCT in quantitative evaluation of left ventricle function in patients with coronary artery disease compared to 2D echocardiography.

Patients and methods

Fifty patients with suspected coronary artery disease underwent contrast enhanced MDCT using retrospective gating without dose modulation. Ten phases of cardiac cycle were processed to assess end-systolic and end-diastolic phase at LV short-axis view. 2DSE was performed in the same day. LVSV, LVDV, LFEF, LVSV were calculated using the Simpson's method in MDCT and modified Simpson's method in echocardiography.

Results

LVSV, LVDV, LVSV, LFEF were 74.30?±?24.92, 185.46?±?56.25, 84.15?±?33.16, 48.88?±?13.32 respectively on MSCT and 71.43?±?21.93, 182.31?±?56.49, 81.74?±?32.88, 47.82?±?13.64 respectively on echocardiography with excellent correlation between the modalities (P?<?0.001) using linear regression analysis. A Bland-Altman analysis showed that MDCT had slightly higher LVSV, LVDV, and LVSV, LFEF values with mean value of differences of 2.9, 3, 2.4 and 1% respectively.

Conclusion

MDCT is an accurate method for quantitative evaluation of global left ventricular function compared to 2D echocardiography.