| 金黄色葡萄球菌万古霉素耐药与凝固酶活性 |
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| 引用本文： | 代洪,范学工.金黄色葡萄球菌万古霉素耐药与凝固酶活性[J].临床检验杂志,2006,24(1):19-22. |
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| 作者姓名： | 代洪 范学工 |
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| 作者单位： | 中南大学湘雅医院传染科,长沙,410008;中南大学湘雅医院传染科,长沙,410008 |
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| 摘 要： | 目的研究在体外诱导万古霉素耐药金黄色葡萄球菌(金葡菌)过程中凝固酶活性、凝固酶DNA表达改变情况.方法检测凝固酶活性;利用coa基因与gyrB基因同步扩增,对coa基因DNA进行半定量.结果有6株金葡菌凝固酶活性降低;检测到1株金葡菌凝固酶基因DAN表达降低.结论金葡菌与万古霉素共孵育后凝固酶活性有不同程度的降低.
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| 关 键 词： | 万古霉素 金黄色葡萄球菌 凝固酶 |
| 文章编号： | 1001-764X(2006)01-0019-04 |
| 收稿时间： | 2005-03-15 |
| 修稿时间： | 2005-07-11 |
Studies on relationship between resistance to vancomycin and the coagulase activity of S. aureus |
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| DAI Hong,FAN Xuegong.Studies on relationship between resistance to vancomycin and the coagulase activity of S. aureus[J].Chinese Journal of Clinical Laboratory Science,2006,24(1):19-22. |
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| Authors: | DAI Hong FAN Xuegong |
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| Institution: | Department of Infectious Disease, Xiangya Hospital, Central South University, Changsha 410008, China |
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| Abstract: | Objective To observe the changes of coagulase activity and the DNA expression of coagulase of S.aureus during inducing vancomycin-resistant S.aureus in vitro.Methods Coagulase activity and DNA expression of coagulase of S.aureus were detected.Results The coagulase activity in 6 strains and the expression of coagulase DNA in 1 strain reduced.Conclusion Decreased coagulase activity and DNA expression are probably linked to vancomycin resistance of S.aureus. |
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| Keywords: | vancomycin drug resistibility coagulase |
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