同等药效学指标下依托咪酯与丙泊酚脑电双频指数值的比较

Objective To measure the predicted plasma and effect-site EC50 and bispeetral index(BIS) of etomidate delivered with TCI,and to compare the difference in BIS value induced by etomidate and propofol at same pharmacodynamics index (EC50 of losing consciousness).Methods Forty seven patients scheduled for surgery were anesthetized with etomidate using TCI.TCL started to get a predicted plasma etomidate concentration of 0.25 mg/L,and increased by 0.03 mg/L every 30 s until patients lost their consciousness.A quantal response model(probit analysis) was used to calculate the predict plasma and effect-site EC50,EC50 and EC95 of etomidate,and the corresponding BIS values were recorded and compared to that induced with propofol reported before.Results The predicted plasma etomidate concentration of EC50 to losing consciousness was 0.59 mg/L with EC05 and EC95 of 0.46,0.71 μg/ml,respectively.The corresponding effect-site concentration of EC50 was 0.51 mg/L with EC05 and EC95 of 0.37 and 0.64 mg/L,respectively.In this study,BIS values to make 50% and 90% of patients losing their consciousness were 44 and 31～56,respectively.The BIS value induced with etomidate(45±10) was markedly lower than that with propofol(58±11) at the same pharmacodynamics index (EC50 of losing consciousness).Conclusion The predicted plasma and effectsite EC50 of etomidate administered with TCI to lose consciousness is 0.59 mg/L and 0.51 mg/L,respectively.The corresponding BIS value with etomidate is markedly lower than that with propofol.

Comparison of bispectral index value induced by etomidate and propofol at same pharmacodynamics index

Objective To measure the predicted plasma and effect-site EC50 and bispeetral index(BIS) of etomidate delivered with TCI,and to compare the difference in BIS value induced by etomidate and propofol at same pharmacodynamics index (EC50 of losing consciousness).Methods Forty seven patients scheduled for surgery were anesthetized with etomidate using TCI.TCL started to get a predicted plasma etomidate concentration of 0.25 mg/L,and increased by 0.03 mg/L every 30 s until patients lost their consciousness.A quantal response model(probit analysis) was used to calculate the predict plasma and effect-site EC50,EC50 and EC95 of etomidate,and the corresponding BIS values were recorded and compared to that induced with propofol reported before.Results The predicted plasma etomidate concentration of EC50 to losing consciousness was 0.59 mg/L with EC05 and EC95 of 0.46,0.71 μg/ml,respectively.The corresponding effect-site concentration of EC50 was 0.51 mg/L with EC05 and EC95 of 0.37 and 0.64 mg/L,respectively.In this study,BIS values to make 50% and 90% of patients losing their consciousness were 44 and 31～56,respectively.The BIS value induced with etomidate(45±10) was markedly lower than that with propofol(58±11) at the same pharmacodynamics index (EC50 of losing consciousness).Conclusion The predicted plasma and effectsite EC50 of etomidate administered with TCI to lose consciousness is 0.59 mg/L and 0.51 mg/L,respectively.The corresponding BIS value with etomidate is markedly lower than that with propofol.