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Reduced 3H-imipramine binding but unaltered 3H-serotonin uptake in platelets of adolescent enuretics
Authors:R Weizman  M Carmi  S Tyano  M Rehavi
Affiliation:1. Population Research Unit, Faculty of Social Sciences, University of Helsinki, Finland;2. International Max Planck Research School for Population, Health and Data Science, Rostock, Germany;3. Institute of Criminology and Legal Policy, Faculty of Social Sciences, University of Helsinki, Helsinki, Finland;4. Law School, University of Eastern Finland, Joensuu, Finland;5. Max Planck Institute for Demographic Research, Rostock, Germany;6. Department of Public Health Sciences, Stockholm University, Sweden;1. School of Health Sciences, Touro University, NY, USA;2. VISN 2 Mental Illness Research, Education and Clinical Center, James J. Peters VA Medical Center, NY, USA;3. Department of Counseling & Clinical Psychology, Teachers College, Columbia University, NY, USA;4. Ferkauf Graduate School of Psychology, Yeshiva University, NY, USA;5. Department of Psychology, Hofstra University, NY, USA;1. NORMENT, Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway;2. Early Intervention in Psychosis Advisory Unit for South East Norway, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway;3. Department of Psychology, University of Oslo, Oslo, Norway;4. Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway;5. Research institute, Modum Bad, Vikersund, Norway;6. INSERM U1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Paris, France;7. Département de Psychiatrie et de Médecine Addictologique, Hôpital Fernand Widal, Assistance Publique des Hôpitaux de Paris (APHP), Paris, France;8. Université Paris Cité, Paris, France;9. Fondation FondaMental, Créteil, France
Abstract:High affinity 3H-imipramine binding and 3H-serotonin uptake to platelets was evaluated in nine untreated adolescent enuretics (ages 13-18) and nine age- and sex-matched controls. A significant decrease in the maximal binding of 3H-imipramine (Bmax) was observed in the enuretics as compared to the controls. No alteration in the affinity of 3H-imipramine to its binding sites (Kd) or in serotonin uptake kinetic parameters (Vmax, Km) was detected. The lack of correlation between Bmax and Vmax values might indicate that the binding sites for imipramine and the sites for serotonin uptake are not identical.
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