| HPLC法测定小儿复方氨基酸注射液(19AA-Ⅰ)中牛磺酸的含量 |
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| 引用本文： | 许文东,闫厚利,张国锋. HPLC法测定小儿复方氨基酸注射液(19AA-Ⅰ)中牛磺酸的含量[J]. 齐鲁药事, 2007, 26(8): 468-469 |
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| 作者姓名： | 许文东 闫厚利 张国锋 |
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| 作者单位： | 山东齐都药业有限公司,山东,淄博,255400 |
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| 摘 要： | 目的建立HPLC法测定小儿复方氨基酸注射液(19AA-Ⅰ)中牛磺酸的分析方法.方法用SHIMADZU VP-ODS色谱柱(250mm×4.6mm,5μm),采用甲醇流动相体系,检测波长为248nm.结果牛磺酸在8μg·mL~25μg·mL-1之间与峰面积线性关系良好(r=0.9998),平均回收率为98.68%(RSD=1.24%).结论方法操作简便、重现性好、灵敏度高、专属性强,可用于小儿复方氨基酸注射液(19AA-Ⅰ)的质量控制.
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| 关 键 词： | 牛磺酸 小儿复方氨基酸注射液(19AA-Ⅰ) 高效液相色谱法 |
| 文章编号： | 1672-7738（2007）08-0468-02 |
Determination of Taurine in Pediatric Compound Amino Acid Injection(19AA-Ⅰ) by HPLC |
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| XU Wen-dong,YAN Hou-li,ZHANG Guo-feng. Determination of Taurine in Pediatric Compound Amino Acid Injection(19AA-Ⅰ) by HPLC[J]. qilu pharmaceutical affairs, 2007, 26(8): 468-469 |
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| Authors: | XU Wen-dong YAN Hou-li ZHANG Guo-feng |
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| Affiliation: | Shandong qidu pharmacy limited company,Zibo 255400 |
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| Abstract: | OBJECTIVE To establish a HPLC method for determination of taurine in Pediatric Compound Amino Acid Injection(19AA-Ⅰ).METHODS The HPLC method was performed on SHIMADZU VP-ODS column,methanol as mobile phase,and detection wavelength was set at 248nm.RESULTS The liner range of taurine was 8μg·ml-1～25μg·ml-1(r=0.9999),the average recovery was 98.68% with RSD=1.24%.CONCLUSION The method is simple,highly repeatable,highly sensitive and specific,and can be used for quality control of Pediatric Compound Amino Acid Injection(19AA-Ⅰ). |
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| Keywords: | Taurine Pediatric Compound Amino Acid Injection(19AA-Ⅰ) HPLC |
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