| 比索洛尔对维持性血液透析患者高血压及心率变异性的影响 |
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| 引用本文： | 成彩联,郑振达,汤颖,刘迅,娄探奇. 比索洛尔对维持性血液透析患者高血压及心率变异性的影响[J]. 中国中西医结合肾病杂志, 2012, 13(6): 501-503 |
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| 作者姓名： | 成彩联 郑振达 汤颖 刘迅 娄探奇 |
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| 作者单位： | 1. 中山大学附属第三医院肾内科,广州,510630
2. 中山大学附属第三医院心内科,广州,510630 |
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| 基金项目： | 广东省科技厅基金资助项目(No.2010B031600202) |
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| 摘 要： | 目的:观察比索洛尔对维持性血液透析患者高血压及心率变异性的疗效。方法:选取2010年6月～12月在我科行维持性血液透析患者33例,在常规高血压治疗基础上加用比索洛尔5～10mg/d,观察时间为6个月,治疗前和治疗6月后检测动态心电图和生化指标。结果:比索洛尔能明显降低维持性血液透析患者的血压(P<0.05),改善心率变异性(P<0.05),减少心律失常的发生率(P<0.05),而对血清总胆固醇、尿酸、血糖没有明显影响(P>0.05)。结论:比索洛尔能改善维持性血液透析患者的心率变异性,是安全有效的治疗措施。
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| 关 键 词： | 比索洛尔 肾透析 心率变异性 |
Effects of Bisoprol on Hypertension and Heart Rate Variability in Maintenance Hemodialysis Patients |
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| Affiliation: | CHENG Cailian,ZHENG Zhenda,TANG Ying,et al Department of Cardiology,the Third Affiliated Hospital of Sum Yat-sen University,Guangzhou(510630) |
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| Abstract: | Objective:To investigate the effects of bisoprolol on hypertension and heart rate variability in maintenance hemodialysis patients.Methods:Thirty-three maintenance hemodialysis patients in the third affiliated hospital of Sun Yat-Sen University were received bisoprolol 5 ～ 10 mg/d addition to basis antihypertensive agents for six months,the patients received holter monitoring before and after the study,systolic and diastolic blood pressure were measured,blood glucose,cholesterol,and uric acid were tested before and after the study.Results:Bisoprolol decreased blood pressure and improved heart rate variability significantly,it also resulted in a significant decrease in the incidence of arrhythmia.However,there were no changes in glucose,cholesterol,and uric acid levels.Conclusion:Bisoprolol can improve heart rate variability and is an effective and safe therapeutic measures for hemodialysis patients with hypertension. |
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| Keywords: | Bisoprolol Hemodialysis Heart rate variability |
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