LPS promotes pre-osteoclast activity by up-regulating CXCR4 via TLR-4 |
| |
Authors: | Xing Q de Vos P Faas M M Ye Q Ren Y |
| |
Institution: | Department of Orthodontics, University Medical Centre Groningen, University of Groningen, Hanzeplein 1 triade 24, 9700 RB Groningen, The Netherlands. |
| |
Abstract: | Lipopolysaccharide (LPS) has been shown to be a prominent pathogenic factor in inflammatory bone loss. However, knowledge of the mechanisms involved is limited. The role of the SDF-1/CXCR4 (Stromal-derived factor-1 and its unique chemokine receptor) axis in LPS-induced bone loss has not been studied. The aim of this study was to investigate the role of the SDF-1/CXCR4 axis in LPS-stimulated inflammatory bone loss. The results show that LPS does not influence the expression of SDF-1/CXCR4 in osteoblasts, but up-regulates the expression of CXCR4 in pre-osteoclasts via Toll-like receptor 4, which subsequently enhances pre-osteoclast migration. Moreover, LPS promoted RANKL-induced osteoclast differentiation partially through CXCR4 up-regulation. In conclusion, the present study demonstrated, for the first time, that the up-regulated expression of CXCR4 in pre-osteoclasts by LPS stimulation is involved in LPS-induced bone resorption. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|