细胞核增殖相关抗原Ki67在子宫内膜病变中的表达

目的：研究Ki67抗原在子宫内膜病变中表达的规律及其在子宫内膜癌的发生和预后评估的临床价值。方法：用免疫组化（SP）法检测子宫内膜增殖症及非典型增生各30例，子宫内膜癌90例；对照组30例，其中包括增生期及分泌期子宫内膜各15例，观察Ki67抗原在不同内膜病变及正常内膜中的阳性表达率。结果：Ki67抗原在分泌期内膜中几乎没有表达，在增生期内膜中有弱表达；在增殖症及非典型增生中有表达，但与对照组比较，无统计学意义（P〉0．05），且两者之间比较，亦无统计学意义（P〉0．05）；在子宫内膜癌组织中表达明显增高，显著高于良性病变组和对照组（P〈0．01）。而且Ki67抗原的阳性率随着临床分期及细胞分化级别的升高及淋巴转移的存在而增加。结论：Ki67抗原与子宫内膜癌发生密切相关．抗原过度表达提示子宫内膜癌患者预后不良。

The Expression of the Proliferation marker Ki67 in Endometrial Disease

Objective: To investigate the expression of the proliferation marker Ki67 in endometrial diseases and its clinical significance for the incidence of endometrial carcinoma and evaluation of prognosis. Method: Experimental group: 150 cases including 30 of endometrial hyperlpasia, 30 of atypical proliferation and 90 of endometrial carcinoma; control group: 30 cases including 15 of proliferative endometrium and 15 of secretory endometrium. The expression of Ki67 in these cases with immunohistochemistry technology was detected. Results: There was almost no Ki67 expression in secretory endometrium and the expression was mild in proliferative endometrium. In endometrial hyperplasia and atypical proliferation, Ki67 expression can be observed but there was no statistically significance between the two groups (P>0.05). Compared with control groups respectively, there was no significance too (P>0.05). In endometrial carcinoma, the expression increased obviously,which is higher than benign diseases and control group prominently (P<0.01). The positive rate of Ki67 antigen increased with the increasing of clinical phase and grade of cellular differentiation. Conclusion: Ki67 antigen is related to the incidence of endometrial carcinoma. The over expression of Ki67 indicates a poor prognosis of patients with endometrial carcinoma.