| 转录因子-kB在妊娠期高血压疾病患者胎盘组织中的表达 |
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| 引用本文： | 杨亚滨,张艳梅,赵艳梅.转录因子-kB在妊娠期高血压疾病患者胎盘组织中的表达[J].中国妇幼保健,2008,23(15):2136-2137. |
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| 作者姓名： | 杨亚滨 张艳梅 赵艳梅 |
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| 作者单位： | 哈尔滨医科大学附属第五医院,163316 |
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| 摘 要： | 目的:检测胎盘组织中转录因子-kB(nuclear factor-kappaB,NF-kB)的表达,探讨其与妊娠期高血压疾病发病的关系。方法:用免疫组化法对18例正常孕妇和50例妊娠期高血压疾病患者(其中妊娠期高血压15例,子痫前期轻度17例、重度18例)胎盘中NF-kB进行检测。结果:妊娠期高血压疾病患者胎盘中的NF-kB表达明显高于正常妊娠组(P<0.05),结论:胎盘组织中的NF-kB表达升高与妊娠期高血压疾病的发病有关。
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| 关 键 词： | 转录因子-kB 妊娠期高血压疾病 胎盘 |
| 文章编号： | 1001-4411(2008)15-2136-02 |
| 修稿时间： | 2007年9月5日 |
Expression of NF-KB in the placenta of patients with hypertensive disorder complicating pregnancy |
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| YANG Ya-Bin,ZHANG Yan-Mei,ZHAO Yan-Mei.Expression of NF-KB in the placenta of patients with hypertensive disorder complicating pregnancy[J].Maternal and Child Health Care of China,2008,23(15):2136-2137. |
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| Authors: | YANG Ya-Bin ZHANG Yan-Mei ZHAO Yan-Mei |
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| Abstract: | Objective:To detect NF-κB in the placenta in order to evaluate the relationship of NF-κB with hypertensive disorder complicating pregnancy.Methods:The expression of NF-κB in 18 nomal and 50 hypertensive disorder complicating pregnancy placenta(15 cases of hypertension complicating pregnancy,17 cases of mild and 18 cases of severe preeclampsia)was detected by immunohistochemistry.Results:The NF-κB expression levels in hypertensive disorder complicating pregnancy group were all significantly higher than those in normal pregnancy group(P<0.05).Conclusion:The elevated expression of NF-κB in the placenta may play an important role in hypertensive disorder complicating pregnancy. |
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| Keywords: | Nuclear factor-kappa B Hypertensive disorder complicating pregnancy Placenta |
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