丁苯酞氯化钠注射液治疗血管性痴呆的疗效观察

目的探讨丁苯酞氯化钠注射液治疗血管性痴呆的临床疗效。方法选择2014年1月—2016年12月襄阳市中心医院神经内科收治的血管性痴呆患者100例,所有患者随机分为对照组和治疗组,每组各50例。对照组给予常规抗血小板聚集、改善脑循环、降脂稳定斑块、神经保护、调控血压血糖等对症治疗。治疗组在对照组基础上静脉滴注丁苯酞氯化钠注射液,25 mg/次,2次/d,滴注时间≥50 min,用药时间间隔≥6 h。两组均连续治疗28 d。观察两组的临床疗效,比较两组的简易精神状况检查量表(MMSE)、蒙特利尔认知评估量表(Mo CA)、日常生活能力量表(ADL)和波士顿诊断性失语症检查(BDAE)评分情况。结果治疗后,对照组和治疗组的总有效率分别为74.0%、92.0%,两组比较差异有统计学意义(P0.05)。治疗28 d后,两组MMSE、Mo CA、ADL和BDAE评分均显著升高,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标明显高于对照组,两组比较差异具有统计学意义(P0.05)。结论丁苯酞氯化钠注射液治疗血管性痴呆具有较好的临床疗效,可显著改善患者的认知功能,促进语言功能和日常生活能力恢复,提高患者的生存质量,安全性较好,具有一定的临床推广应用价值。

Clinical observation of Butylphthalide and Sodium Chloride Injection in treatment of vascular dementia

Objective To investigate the clinical effect of Butylphthalide and Sodium Chloride Injection in treatment of vascular dementia. Methods Patients (100 cases) with vascular dementia in Xiangyang Central Hospital from January 2014 to December 2016 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were given conventional anti-platelet aggregation, improved cerebral circulation, lipid-lowering, stable plaque, nerve protection, regulation of blood pressure and blood sugar, and symptomatic treatment. Patients in the treatment group were iv administered with Butylphthalide and Sodium Chloride Injection on the basis of the control group, 25 mg/time, twice daily, infusion time ≥ 50 min, medication interval ≥2 h. Patients in two groups were treated for 28 d. After treatment, the clinical efficacies were evaluated, and the scores of MMSE, MoCA, ADL, and BDAE in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 74.0% and 92.0%, respectively, and there was difference between two groups (P < 0.05). After treatment for 28 d, the scores of MMSE, MoCA, ADL, and BDAE in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Butylphthalide and Sodium Chloride Injection has clinical curative effect in treatment of vascular dementia, can significantly improve cognitive function, promote the recovery of the language function and the daily living ability, and improve quality of life, with good safety, which has a certain clinical application value.