Patterns of care and survival of glioblastoma patients: A comparative study between 2004 and 2008 in Lyon,France |
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| Authors: | N. Badaoui,D. Meyronet,S. Cartalat-Carel,J. Guyotat,E. Jouanneau,A. d&rsquo Hombres,M.P. Sunyach,A. Jouvet,G. Louis-Tisserand,A. Archinet,D. Frappaz,L. Bauchet,J. Honnorat,F. Ducray |
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| Affiliation: | 1. Service de neuro-oncologie, hôpital neurologique Pierre-Wertheimer, Hospices Civils de Lyon, 59, boulevard Pinel 69394 Lyon cedex, France;2. Université de Lyon, Claude-Bernard Lyon 1, 43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex, France;3. Lyon Neuroscience Research Center INSERM U1028/CNRS UMR 5292, centre de recherche en neurosciences de Lyon, équipe neuro-oncologie et neuro-inflammation, faculté Laënnec, 8, rue G.-Paradin, 69008, Lyon, France;4. Service de neuropathologie, hôpital neurologique Pierre-Wertheimer, groupe hospitalier Est, Hospices Civils de Lyon, 59, boulevard Pinel 69394 Lyon cedex, France;5. Service de neurochirurgie D, hôpital neurologique Pierre-Wertheimer, groupe hospitalier Est, Hospices Civils de Lyon, 59, boulevard Pinel 69394 Lyon cedex, France;6. Service de neurochirurgie A, hôpital neurologique Pierre-Wertheimer, groupe hospitalier Est, Hospices Civils de Lyon, 59, boulevard Pinel 69394 Lyon cedex, France;g Service de radiothérapie oncologie, centre hospitalier Lyon Sud, Hospices Civils de Lyon, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France;h Centre Léon-Bérard, 28, Promenade-Léa et Napoléon-Bullukian, 69008 Lyon, France;i Service de neuro-radiologie, hôpital neurologique Pierre-Wertheimer, groupe hospitalier Est, Hospices Civils de Lyon, 59, boulevard Pinel 69394 Lyon cedex, France;j Service de neurochirurgie, centre Gui-de-Chauliac, CHU de Montpellier, 2, avenue Emile-Bertin-Sans, 34295 Montpellier, France |
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| Abstract: | IntroductionThe treatment of glioblastomas (GBMs) has changed significantly since 2005. However, the extent to which this change has improved overall survival (OS) of patients treated outside clinical trials remains to be determined.MethodsWe compared the patterns of care and OS of all GBM patients diagnosed in 2004 (n = 105) and in 2008 (n = 130) in our center.ResultsYounger patients (aged < 70 years) diagnosed in 2008 received temozolomide radiochemotherapy as the initial treatment and bevacizumab at recurrence more frequently than those diagnosed in 2004 (69% vs 26% P < 10−4 and 41% vs 3%, P < 10−4, respectively). Elderly patients (aged ≥ 70 years) diagnosed in 2008 received an oncological treatment (radiotherapy and/or chemotherapy) more frequently than those diagnosed in 2004 (67% vs 38%, P = 0.006). The patients diagnosed in 2008 had longer OS than those diagnosed in 2004 (10.5 months vs 5.3 months, P = 0.001). This finding was true for both younger and elderly patients (15.3 months vs 8.9 months, P = 0.02 and 6.4 months vs 3.2 months, P = 0.0002, respectively) and when considering only IDH1 wild-type patients (8.9 months vs 5.3 months, P = 0.004).ConclusionIn our center, the change in the patterns of care for GBMs between 2004 and 2008 has been associated with a significant improvement in OS. |
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| Keywords: | Glioblastoma Epidemiology Patterns of care Temozolomide Bevacizumab |
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