| Abstract: | Sulphatides were assayed in preparations of frontal cortex, neostrialum and hippocampus of 6-month-old male spontaneously hypenensive rats (SHR, systolic pressure 215 ± 6 mmHg) and age-matched normotensive Wistar-Kyoto (WKY) rats (systolic pressure 143 ±6 mm Hg) by thin layer chromatography associated with spectrophotometry and histochemistry. The volume of gray and white matter of the above areas was also measured by microanatomical techniques associated with image analysis. Sulphatide levels were unchanged in the frontal cortex and neostriatum and decreased in the hippocampus of SHR in comparison with WKY rats. No changes of metachromatic sulphatide staining were found in the different brain areas investigated of SHR, whereas a decrease of positive metachromatic areas was noticeable in the frontal cortex and neostriatum |
