Nanostructured lipid carriers as a delivery system of biochanin A

Abstract

The aim of this study was to explore the nanostructured lipid carriers as a delivery system of biochanin A so as to supply a method to improve its bioavailability. Biochanin A–loaded nanostructured lipid carriers (BCA-NLCs) were prepared by the method of emulsion-evaporation and low temperature solidification. Pharmacokinetics was carried out in rats upon oral administration at a dose of 10?mg/kg. BCA-NLC showed spherical formulation and had mean diameter174.68?±?0.96?nm, zeta potential ?20.9?±?0.8?mv and entrapment efficiency 97.36?±?0.14%. DSC and XRD studies indicated that BCA was not in crystal state in NLC. In in vitro release study, the BCA from BCA-NLC exhibited a biphasic release pattern with burst release initially and sustained release afterwards. BCA-NLC showed higher AUC value and circulated in blood for a longer time than BCA suspension. The studies demonstrated that NLC could be a potential delivery system for BCA to improve bioavailability.