乳腺浸润性导管癌中COX-2、MMP-9的表达及临床意义

目的：探讨COX-2和MMP-9蛋白：在乳腺浸润性导管癌组织中的表达及其相关性。方法-应用免疫组织化学法检测52例乳腺癌组织COX-2和MMP-9蛋白的表达。结果：乳腺浸润性导管癌组织中COX-2阳性表达率为76．9％（40／52），MMP-9阳性表达率为82．7％（43／52），COX-2阳性表达与患者的年龄、肿瘤大小、雌孕激素受体无明显相关性（P〉0．05），而与淋巴结转移、TNM分期、组织学分级有关（P〈0．05）；MMP-9阳性表达与患者的年龄、雌孕激素受体无明显相关性（P〉0．05），而与肿瘤大小、淋巴结转移、TNM分期、组织学分级有关（P〈0．05）；乳腺浸润性导管癌组织中COX-2、MMP-9蛋白的表达之间存在显著正相关（r=0．448，P〈0．01）。结论：乳腺浸润性：导管癌组织中COX-2、MMP-9蛋白高表达，且两者具相关性。COX-2蛋白可通过诱导MMP-9蛋白如殳达匕调，增加孚嘣塘细胞的侵袭力，促进乳腺癌浸润、转移。

Expression and significance of COX- 2 and MMP -9 in invasive ductal carcinoma of breast

Objective： To study the expression and the correlation of cyclooxygenase - 2 （ COX - 2 ） and matrix metalloproteinase - 9 （ MMP - 9 ） in invasive ductal carcinoma of breast. Methods： Expression of COX - 2 and MMP - 9 was detected in 52 cases of breast cancer tissue by immunohistochemistry. Results ： Positive rate of COX - 2 was 76.9% （40/52）, positive rate of MMP -9 was 82.7 % （43/52） in invasive ductal carcinoma of breast. The positive expression of COX - 2 was related with lymph node metastasis, TNM stage and histological grade, but negatively correlated to age, tumor size, estrogen receptor, progestin receptor（ P 〉0. 05 ） ;The expression of MMP- 9 was associated with tumor size, TNM stage, lymph node metastasis and histological grade （ P 〈 0.05 ）, but negatively correlated to age, estrogen receptor, progestin receptor. There was a significant correlation between the expression of COX- 2 and MMP - 9 in breast cancer（ r = 0.448, P 〈 0. 01 ）. Conclusion： COX - 2 and MMP - 9 are overexpressed in invasive ductal carcinoma of breast. COX -2 could promote the invasion and metastasis of human breast cancer through up - regulating the expression of MMP - 9.