Cyclin D as a therapeutic target in cancer |
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| Authors: | Musgrove Elizabeth A Caldon C Elizabeth Barraclough Jane Stone Andrew Sutherland Robert L |
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| Affiliation: | Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney NSW 2010, Australia. |
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| Abstract: | Cyclin D1, and to a lesser extent the other D-type cyclins, is frequently deregulated in cancer and is a biomarker of cancer phenotype and disease progression. The ability of these cyclins to activate the cyclin-dependent kinases (CDKs) CDK4 and CDK6 is the most extensively documented mechanism for their oncogenic actions and provides an attractive therapeutic target. Is this an effective means of targeting the cyclin D oncogenes, and how might the patient subgroups that are most likely to benefit be identified? |
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